急性脑梗死患者血尿酸水平与颈动脉粥样硬化的相关性研究

目的 探讨并分析脑梗死患者的血尿酸水平与颈动脉粥样硬化之间的相关性。 方法 选取2016年1月—2018年7月间蚌埠医学院第二附属医院收治的急性脑梗死患者90例为研究对象，记录一般资料，对所有入选患者进行颈动脉彩色多普勒超声检查，根据斑块的有无及稳定性分为稳定斑块组、不稳定斑块组、无斑块组各30例。测定并对比不同组别的患者血尿酸水平及C反应蛋白水平相关指标，分析比较尿酸对颈动脉粥样硬化斑块形成的作用。 结果 3组患者血尿酸水平的比较之间的差异有统计学意义(P<0.05)，其中无斑块组与稳定斑块组及不稳定斑块组比较，差异有统计学意义(均P<0.05)，稳定斑块组与不稳定斑块组之间比较时，差异无统计学意义(P>0.05)。3组患者C反应蛋白水平的比较之间的差异有统计学意义(P<0.05)，其中无斑块组与稳定斑块及不稳定斑块差异有统计学意义(均P<0.05)，稳定斑块组与不稳定斑块组之间差异无统计学意义(P>0.05)。 结论 急性脑梗死患者高血尿酸水平与颈动脉粥样硬化斑块发生发展密切相关，但是颈动脉粥样硬化斑块的稳定性与血尿酸水平无明显相关性。血尿酸水平的升高提示患者有形成颈动脉粥样硬化斑块的风险，临床上可以根据患者血尿酸水平，及时给予适当的干预。 

Correlation analysis of serum uric acid levels and carotid atherosclerosis in patients with acute cerebral infarction

Objective To explore and analyze the correlation between blood uric acid and carotid atherosclerosis in patients with cerebral infarction. Methods A total of 90 patients with acute cerebral infarction in our hospital from January 2016 to July 2018 were enrolled as the research participants. General data were recorded. All patients were examined by carotid artery color Doppler ultrasonography. According to the presence and stability of plaque, they were divided into three groups: stable plaque group, unstable plaque group and non-plaque group. The blood uric acid level and C-reactive protein level related indicators in different group were measured, and the effect of uric acid on plaque formation was analyzed. Results There were significant differences in serum uric acid levels among the three groups (P<0.05) with significant difference between the non-plaque group and the stable plaque group and the unstable plaque group (all P<0.05). There was no significant difference between stable plaque group and unstable plaque group (P>0.05). There were significant differences in C-reactive protein levels among the three groups (P<0.05), among which there were significant differences between the non-plaque group and the stable plaque group and the unstable plaque group (all P<0.05); there was no difference between the stable plaque group and the unstable plaque group (P>0.05). Conclusions The level of hyperuricemia in patients with acute cerebral infarction is closely related to the occurrence of carotid atherosclerotic plaque, but the stability of carotid atherosclerotic plaque has no significant correlation with the level of serum uric acid. The elevated serum uric acid level suggests that patients have the risk of carotid atherosclerosis plaque formation. Clinically, appropriate intervention can be given in time according to the serum uric acid level.