乳腺黏液癌的MRI表现及与临床病理特征相关性分析

目的:探讨分析乳腺黏液癌（mucinous breast carcinoma，MBC）的MRI影像学特征及临床病理特征。方法:收集2010年1月至2016年12月间临床资料完整的乳腺黏液癌患者75例，其中单纯型乳腺黏液癌（Pure MBC）患者54例，混合型乳腺黏液癌（Mixed MBC）患者21例。分析比较两组患者的MRI影像学表现和临床病理特征。结果:在两组乳腺癌患者中，单纯型乳腺黏液癌与混合型乳腺黏液癌比较，混合型乳腺黏液癌更多表现为淋巴结阳性(P=0.002)；在年龄、月经状况、家族史、雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）水平方面差异无统计学意义（P<0.05）；在MRI检查方面，肿块平均大小及肿块边缘、形态、强化方式、强化程度及表观弥散系数(ADC)差异具有统计学意义(P<0.001)。结论:了解乳腺黏液癌的MRI影像学及临床病理特征，可帮助临床医师预测乳腺黏液癌及其亚型和患者的预后，有利于制定最优的治疗方案。

MRI and clinicopathologic characteristics correlatively analysis of breast mucinous carcinoma

Objective:To study the clinicopathologic characteristics and MRI feature of breast mucinous cancer（MBC).Methods:There were 75 cases mucinous breast cancer（MBC) patients in this study between January 2010 and December 2016.There were 54 cases of pure MBC，21 cases of mixed MBC.The clinicopathologic characteristics and MRI feature were retrospectively analyzed.Results:Statistical analysis showed that pure MBC differed from mixed MBC with respect to lymph node status（P=0.002)，mixed MBC showed lymph node postive.No significant difference was observed in terms of age，menstrual status，family history，ER，PR，HER2 status（P<0.05).In MRI，there were significant differences in mean size of mass，margin of mass，shape of mass，T2WI，internal mass enhancement，intensity-time curves，ADC（P<0.001).Conclusion:To analysis the MRI and clinical pathology features may help predict the type of breast mucinous carcinoma and it's prognosis，and to select an optimal treatment plan for patients with different subtypes of breast mucinous cancer．