| PCDH20在恶性肿瘤中的研究进展 |
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| 引用本文： | 石文文1,支园园1,成秉林2,郭林顿3,成 浩4,张淑君1. PCDH20在恶性肿瘤中的研究进展[J]. 现代肿瘤医学, 2019, 0(20): 3717-3720. DOI: 10.3969/j.issn.1672-4992.2019.20.039 |
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| 作者姓名： | 石文文1 支园园1 成秉林2 郭林顿3 成 浩4 张淑君1 |
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| 作者单位： | 1.哈尔滨医科大学附属第四医院病理科，黑龙江 哈尔滨 150001；2.哈尔滨医科大学附属第一医院中西医结合科，黑龙江 哈尔滨 150001；3.哈尔滨医科大学（大庆校区）医学检验与技术学院，黑龙江 哈尔滨 163319；4.哈尔滨医科大学基础医学院，黑龙江 哈尔滨 150081 |
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| 基金项目： | 黑龙江省自然科学基金资助项目（编号:H2015094） |
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| 摘 要： | 原钙黏蛋白20(PCDH20)是一种带有亲同种抗原结合活性的跨膜蛋白，为原钙黏蛋白家族组成部分之一。研究发现，它的编码基因存在于13q21染色体。PCDH20参与神经系统的生长发育及脊髓背角骨癌疼痛相关兴奋性突触的形成,并可以通过各种机制参与癌症的发生发展。研究结果初步证明其可以作为多种肿瘤的抑制基因，在肝癌、喉鳞癌等多种恶性肿瘤的发生发展中发挥着重要意义。有望为肿瘤的诊疗提供新的思路和方案。本文就近年来对PCDH20在恶性肿瘤中的研究进展作一综述。
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| 关 键 词： | PCDH20 诊断 恶性肿瘤 |
The research progress of PCDH20 associated with malignant tumor |
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| Shi Wenwen1,Zhi Yuanyuan1,Cheng Binglin2,Guo Lindun3,Cheng Hao4,Zhang Shujun1. The research progress of PCDH20 associated with malignant tumor[J]. Journal of Modern Oncology, 2019, 0(20): 3717-3720. DOI: 10.3969/j.issn.1672-4992.2019.20.039 |
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| Authors: | Shi Wenwen1 Zhi Yuanyuan1 Cheng Binglin2 Guo Lindun3 Cheng Hao4 Zhang Shujun1 |
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| Affiliation: | 1.Department of Pathology，the Fourth Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150001，China;2.Department of Integrated Tradition Chinese and Western Medicine Oncology，the First Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150001，China；3.College of Medical Laboratory and Technology，Harbin Medical University（Daqing），Heilongjiang Harbin 163319，China；4.Basic Medical College，Harbin Medical University，Heilongjiang Harbin 150081，China. |
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| Abstract: | Protocadherin 20 (PCDH20) is a transmembrane protein with pro-homologous antigen-binding activity,and it is one of the components of procalmodulin family.Studies have found that its coding gene exists on chromosome 13q21.PCDH20 participates in the growth and development of the nervous system and spinal dorsal horn of bone cancer pain excitatory synapse formation,and can involve in cancer development through a variety of mechanisms.Preliminary research results prove that it can serve as a wide variety of tumor suppressor genes,and in hepatocellular carcinoma,laryngeal squamous carcinoma and others plays a very important significance in development and incidence of malignant tumors.It is expected to provide new ideas and plans for the diagnosis and treatment of tumors.In this paper,the recent progress of PCDH20 in malignant tumor is reviewed. |
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| Keywords: | PCDH20 diagnosis malignant tumor |
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