长春西汀联合小牛血清去蛋白治疗腔隙性脑梗死的临床疗效分析

目的 本研究旨在评估长春西汀联合小牛血清去蛋白治疗腔隙性脑梗死的临床效果。 方法 选取2015年1月1日—2018年8月31日在安徽医科大学第四附属医院急诊内科接受治疗的急性腔隙性脑梗死患者150例，利用随机数字表法随机分为观察组(75例)和对照组(75例)。观察组接受长春西汀静脉滴注30 mg/d，小牛血清去蛋白注射液静脉滴注20 mL/d，连续治疗10 d，以及其他常规治疗；对照组接受小牛血清去蛋白注射液静脉滴注20 mL/d，连续治疗10 d，以及其他常规治疗。在治疗前，治疗后7、14和90 d评估患者的简易精神状态量表(MMSE)、美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表和Barthel指数(BI)评分。 结果 与对照组相比较，治疗90 d后，观察组的MMSE和BI评分显著升高，NIHSS评分下降(均P＜0.05)，提示观察组患者的认知功能、神经功能和生活质量得到了明显的改善。在治疗前和治疗后7 d，2组上述量表评分和药物副作用差异无统计学意义。 结论 作为腔隙性脑梗死急性期治疗的组成部分，长春西汀联合小牛血清去蛋白可以明显改善患者的认知功能、神经功能和生活质量，是一种有效且安全的治疗方法。 

Clinical effect analysis of vinpocetine combined with calf serum deproteination in the treatment of lacunar infarction

Objective To evaluate the clinical effects of vinpocetine combined with calf serum deproteination in the treatment of lacunar infarction. Methods A total of 150 patients with acute lacunar infarction who underwent emergency medical clinic in our hospital from January 2015 to August 2018 were randomly divided into observation group (n=75) and control group (n=75). The observation group received intravenous injection of vinpocetine 30 mg/d, intravenous infusion of calf serum deproteinized injection 20 mL/d for 10 days, and other conventional treatments; the control group received intravenous infusion of calf serum deproteinized injection. Twenty mL/d for 10 days, as well as other conventional treatments. Patients were assessed for the mini mental state scale (MMSE), the national institutes of health stroke scale (NIHSS), the Modified Rankin Scale, and the Barthel index (BI) scores at 7, 14 and 90 days after treatment. Results Compared with the control group, the MMSE, NIHSS and BI scores of the observation group increased significantly after 90 days of treatment (both P<0.05), suggesting that the cognitive function, neurological function and quality of life of the observation group were significantly improved. There were no significant differences of the scores of MMSE, NIHSS and BI tests, as well as the drug side effects between the two groups of patients. Conclusion As part of the treatment of acute lacunar infarction, vinpocetine combined with calf serum deproteinization can significantly improve the cognitive function, neurological function and quality of life of patients, and it is an effective and safe treatment.