Ki67表达比例对乳腺癌患者预后影响的Meta分析

目的:系统评价Ki67表达比例对乳腺癌患者预后的影响,尤其是对无病生存期(DFS)的影响。为临床应用提供循证医学依据。方法:计算机检索PubMed、Embase、Web of Science、Cochrane Library、中国期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库以及中国生物医学文献数据库(CBM)。应用RevMan 5.3软件对所纳入的数据进行统计学分析。结果:共纳入8篇文献,合计15 643例患者。Meta分析结果显示,纳入文献中的Ki67高比例表达组患者的DFS(HR=1.86,95%CI=1.31～2.65)要低于Ki67低比例表达组,差异有统计学意义。亚组分析中,以种族分亚组的结果与上述类似,差异也有统计学意义;以Ki67表达临界值分亚组,Ki67表达临界值为30%的亚组差异没有统计学意义,表达临界值为其他值的亚组差异有统计学意义。结论:本研究Meta分析显示,Ki67是乳腺癌的一种不良预后因子,Ki67高比例表达的患者有着更低的DFS。

Meta-analysis of the effect of Ki67 expression ratio on the prognosis of breast cancer patients

Objective:To systematically evaluate the effect of Ki67 expression ratio on the prognosis of breast cancer，especially the effect of DFS.To provide evidence-based medical basis for clinical application.Methods:The computer retrieves PubMed，Embase，Web of Science，the Cochrane Library，CNKI，VIP database，the Wanfang data base，and the Chinese Biomedical Literature Database（CBM).The included data were statistically analyzed by the RevMan 5.3 software.Results:A total of 8 articles were included.The number of the patients was 15 643.Results of the Meta-analysis showed that the Ki67 high ratio expression group patients' DFS（HR=1.86，95%CI=1.31~2.65) in all the included literatures was lower than the Ki67 low ratio expression group patients，and the difference was statistically significant.In subgroup analysis，the results of ethnic subgroup were similar to the above results，and the difference was also statistically significant.There was not statistically significant in the cut off value of Ki67 expression ratio 30% groups.But the difference was statistically significant in the different cut off value of Ki67 expression ratio.Conclusion:Meta-analysis showed that Ki67 was a prognostic factor of breast cancer.The patients with a higher ratio will gain a lower DFS.