以呃逆为首发症状的42例Cushing溃疡合并出血患者的回顾性研究

目的探讨呃逆是否可作为Cushing溃疡合并出血的首发症状值得引起临床重视。 方法回顾性研究42例以呃逆为首发症状的Cushing溃疡合并出血患者的病历资料，分析呃逆首次出现时间与第1个24 h胃肠减压引流量之间的关系，比较1 h内综合治疗和超过1 h治疗的患者的出血持续时间、血流动力学不稳定发生率、病死率之间的差别。 结果呃逆首次出现时间与第1个24 h内胃肠减压引流量之间存在相关性（pearson相关系数r=-0.802）。呃逆发生1 h内治疗组较超过1 h治疗组出血持续时间缩短，出现血流动力学不稳定的发生率更低，病死率更低，差异均有统计学意义（P均<0.05）。 结论呃逆首次出现时间与第1个24 h胃肠减压引流量之间存在负相关，在呃逆出现1 h内诊断Cushing溃疡合并出血，及时进行综合治疗对患者更有益。

Retrospective study on 42 patients of cushing ulcer with bleeding in the first symptom of hiccup

ObjectiveTo explore whether it is worthy of clinical attention of hiccup can be regarded as the first symptom of Cushing ulcer with bleeding or not. MethodsA retrospective study of 42 cases with Cushing ulcer and bleeding as the first symptom of hiccup was given to analyze the relationship between the first appearance time of hiccup and the first 24 h gastrointestinal decompression drainage, compare the difference in duration of hemorrhage, incidence of hemodynamic instability, and mortality between patients who received comprehensive therapy within 1 h and those who received more than 1 h of treatment. ResultsThere was a correlation between the first appearance of hiccup and the gastrointestinal decompression drainage within the first 24 h (pearson correlation coefficien r=-0.802). The group of intervention within 1 h had shorter duration of bleeding, lower incidence of hemodynamic instability and mortality (P<0.05). ConclusionThe first moment of hiccup has a negative correlation with gastrointestinal decompression and drainage volume within 24 h, the diagnosis of Cushing ulcer combined with hemorrhage within 1 h of hiccup occurres, and timely comprehensive treatment is more beneficial for patients.