| 结核病患者疱疹病毒感染及免疫功能状态的研究 |
| |
| 引用本文： | 陈廷,聂尚丹,赵建磊,杨海霞,李雷生,张孝侠.结核病患者疱疹病毒感染及免疫功能状态的研究[J].中国病原生物学杂志,2011(6). |
| |
| 作者姓名： | 陈廷 聂尚丹 赵建磊 杨海霞 李雷生 张孝侠 |
| |
| 作者单位： | 济宁医学院继续教育学院;济宁医学院医学检验系;山东省胶州市卫生局; |
| |
| 摘 要： | 目的了解肺结核患者疱疹病毒感染及免疫功能状态,探讨红细胞免疫功能与T淋巴细胞亚群可能存在的相关性。方法肺结核患者51例,健康体检者30例,采用金标免疫斑点渗滤法检测血浆单纯疱疹病毒(HSV)、EB病毒、人巨细胞病毒(HCMV)Ig M和IgG抗体;酵母菌花环法检测红细胞受体花环率及红细胞免疫复合物花环率;SAP法检测其外周血CD3+T、CD4+T、CD8+T淋巴细胞百分率。结果肺结核患者组HSV-Ig M、EBV-Ig M阳性率分别为88.24%和60.78%,健康对照组分别为66.67%和30.00%,差异均有统计学意义(P<0.05);肺结核患者组HSV-IgG、EBV-IgG、HCMV-Ig M、HCMV-IgG阳性率为80.39%、41.18%、9.80%和39.22%,健康对照组为70.00%、26.70%、0和30.00%,差异均无统计学意义(P>0.05);肺结核患者红细胞C3b受体花环率低于健康对照组(P<0.01),IC花环率高于健康对照组(P<0.01),CD3+、CD4+T淋巴细胞百分率和CD4+/CD8+比值均低于健康对照组(P<0.01)。结论结核病患者存在HSV和EBV的活化感染,...
|
| 关 键 词： | 结核病 疱疹病毒 感染 红细胞免疫 SAP法 T淋巴细胞亚群 |
Detection of herpes virus infection in and immune function of tuberculosis patients |
| |
| CHEN Ting,NIE Shang-dan,ZHAO Jian-lei,YANG Hai-xia,LI Lei-sheng,ZHANG Xiao-xia.Detection of herpes virus infection in and immune function of tuberculosis patients[J].Journal of Pathogen Biology,2011(6). |
| |
| Authors: | CHEN Ting NIE Shang-dan ZHAO Jian-lei YANG Hai-xia LI Lei-sheng ZHANG Xiao-xia |
| |
| Institution: | CHEN Ting1,NIE Shang-dan2,ZHAO Jian-lei3,YANG Hai-xia2,LI Lei-sheng2,ZHANG Xiao-xia2(1.School of Continuing Education,Jining Medical University,Jining 272013,Shandong,China,2.Department of Medical Laboratory Science,3.Jiaozhou Health Bureau of Shandong Province) |
| |
| Abstract: | Objective To learn about herpes virus infection in tuberculosis patients and T-lymphocyte subsets in those patients and to explore the possible relationship between the immune function of red blood cells and T-lymphocyte subsets.Methods Samples were collected from 51 patients with tuberculosis and 30 normal subjects.A dot-immunogold filtration assay was used to test for IgG and IgM antibodies against HSV,EBV,or HCMV infection.Yeast rosetting was used to measure red blood cell receptors and red blood cell im... |
| |
| Keywords: | Tuberculosis herpes virus infection immunity of red blood cells SAP T-lymphocyte subset |
| 本文献已被 CNKI 等数据库收录！ |
|
