| IL-5及嗜酸粒细胞与人芽囊原虫病患者肠黏膜损伤关系的探讨 |
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| 引用本文： | 俞开敏.IL-5及嗜酸粒细胞与人芽囊原虫病患者肠黏膜损伤关系的探讨[J].中国病原生物学杂志,2011(5). |
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| 作者姓名： | 俞开敏 |
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| 作者单位： | 广西壮族自治区人民医院; |
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| 摘 要： | 目的探讨IL-5及嗜酸性粒细胞与人芽囊原虫病患者肠黏膜损伤的关系。方法实验组为确诊为人芽囊原虫感染的30例患者,对照组为30例健康体检者。均做电子肠镜检查,用ELISA法检测肠黏膜组织匀浆中的IL-5水平。实验组取病变黏膜做病理检查,HE染色病理切片,并观察嗜酸性粒细胞的浸润情况。结果经电子肠镜检查,30例人芽囊原虫病患者均出现不同程度的肠道病变,表现为充血、水肿、糜烂、溃疡等。病理学观察病变组织有嗜酸性粒细胞浸润。实验组肠黏膜组织匀浆IL-5(45.75±24.1)pg/ml,对照组为(19.90±7.6)pg/ml,差异有统计学意义(t=5.603 0,P<0.01),且人芽囊原虫感染者肠黏膜组织匀浆IL-5水平随着浸润嗜酸性粒细胞数目增加而逐渐升高,人芽囊原虫感染度与嗜酸性粒细胞浸润数目呈正相关(rs=0.771 1,P<0.01)。结论人芽囊原虫感染能引起患者肠黏膜的病理改变,嗜酸性粒细胞浸润及细胞因子IL-5水平升高。IL-5和嗜酸性粒细胞在人芽囊原虫感染所致的肠黏膜损伤中起重要作用,且IL-5是人芽囊原虫感染引起免疫反应导致肠黏膜损伤的重要细胞因子之一。
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| 关 键 词： | 人芽囊原虫 IL-5 嗜酸性粒细胞 肠黏膜 损伤 |
The relationship between IL-5,eosinophils and intestinal mucosa lesions in the patients with Blastocystis hominis infection |
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| YU Kai-min.The relationship between IL-5,eosinophils and intestinal mucosa lesions in the patients with Blastocystis hominis infection[J].Journal of Pathogen Biology,2011(5). |
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| Authors: | YU Kai-min |
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| Institution: | YU Kai-min(The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China) |
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| Abstract: | Objective To investigate the relationship between IL-5,eosinophils,and intestinal mucosa lesions in patients with Blastocystis hominis infection.Methods Thirty patients who were diagnosed with B.hominis infection served as the experimental group and 30 healthy persons served as the control group.Endoscopy and intestinal biopsy were performed to observe pathologic changes in the intestine.The patients' and the controls' intestinal tissue homogenate were tested for IL-5 with ELISA assays.The patients' eosinop... |
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| Keywords: | Blastocystis hominis IL-5 eosinophils intestinal mucosa lesion |
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