| 院内感染肠球菌的同源性及耐药性分析 |
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| 引用本文： | 黄辉,陈颖,周建党,易琦峰.院内感染肠球菌的同源性及耐药性分析[J].中国病原生物学杂志,2011(7). |
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| 作者姓名： | 黄辉 陈颖 周建党 易琦峰 |
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| 作者单位： | 中南大学湘雅三医院; |
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| 基金项目： | 国家自然科基金项目(No.20875026); 湖南省科技项目(No.2010FJ4100) |
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| 摘 要： | 目的了解医院感染肠球菌的同源性及耐药状况,为临床控制肠球菌感染及合理使用抗生素提供依据。方法运用随机引物扩增(RAPD)对27株院内感染肠球菌进行基因分型与同源性分析,琼脂稀释法检测7种抗生素对肠球菌的最低抑菌浓度。结果 27株肠球菌经RAPD聚类分析分为9个基因型,27株肠球菌对青霉素、氨苄西林、左旋氧氟沙星、红霉素、多西环素及万古霉素的耐药率分别为85.2%、66.7%、51.9%、51.9%、37.0%和7.4%。结论肠球菌感染以内源性感染为主,同时存在小规模的医院内交叉感染。肠球菌对抗生素的耐药状况日趋严重,万古霉素对肠球菌具有良好抗菌作用。
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| 关 键 词： | 肠球菌 交叉感染 RAPD 聚类分析 耐药性 |
Analysis of the homology and drug resistance of Enterococci causing nosocomial infections |
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| HUANG Hui,CHEN Ying,ZHOU Jian-dang,YI Qi-feng.Analysis of the homology and drug resistance of Enterococci causing nosocomial infections[J].Journal of Pathogen Biology,2011(7). |
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| Authors: | HUANG Hui CHEN Ying ZHOU Jian-dang YI Qi-feng |
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| Institution: | HUANG Hui,CHEN Ying,ZHOU Jian-dang,YI Qi-feng (The Third Xiangya Hospital of Central South University,Changsha 410013,China) |
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| Abstract: | Objective To ascertain the homology and drug resistance of Enterococci causing nosocomial infections to provide a basis for the clinical control of enterococcal infection and proper use of antibiotics.Methods Random amplified polymorphic amplification was used to analyze the genotypes and homology of 27 stains of Enterococci causing nosocomial infections,and the minimal inhibitory concentrations(MIC) of 7 antibiotics were determined using the Kirby-Bauer test.Results The 27 strains of Enterococci causing no... |
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| Keywords: | Enterococcus cross infection RAPD cluster analysis drug resistance |
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