Demethylation and cleavage of glycosidic bonds of 4‴-methyldigoxin in man |
| |
| Authors: | N. Rietbrock Ch. Rennekamp H. Rennekamp K. v. Bergmann U. Abshagen |
| |
| Affiliation: | (1) Institut für Klinische Pharmakologie des Klinikum Steglitz der Freien Universität Berlin, Berlin, Germany |
| |
| Abstract: | Summary In man the oral or intravenous administration of 4 -methyldigoxin yields metabolites in urine which are soluble either in chloroform or in water. The chromatographic analysis reveals demethylation as the main metabolic reaction in man. In addition to methyldigoxin and digoxin small amounts of digoxigenin-bisdigitoxoside and digoxigenin-mono-digitoxoside can be detected. The water soluble metabolites represent 7% of the radioactivity excreted in 7 days reaching a maximum within the first 8 h. |
| |
| Keywords: | Urinary Excretion Methyldigoxin Digoxin Metabolites |
| 本文献已被 SpringerLink 等数据库收录！ |
