| 口服药物吸收的细胞模型研究进展 |
| |
| 引用本文： | 江雪,奚泉,周建平,金方. 口服药物吸收的细胞模型研究进展[J]. 世界临床药物, 2012, 0(5): 292-297 |
| |
| 作者姓名： | 江雪 奚泉 周建平 金方 |
| |
| 作者单位： | 中国药科大学药剂学教研室;中国医药工业研究总院上海医药工业研究院,上海呼吸系统药物工程技术研究中心 |
| |
| 摘 要： | 多种细胞模型如最常用的Caco-2和MDCK细胞,以及新近开发的MDCK-MDR1、M细胞、药物溶出/Caco-2细胞组合、HT-29和TC7细胞等均可用于口服药物吸收的评价,但也存在一定的局限性。本文综述各类细胞模型的特点及其应用等相关研究进展。
|
| 关 键 词： | 口服药物 细胞模型 Caco-2细胞 MDCK细胞 M细胞 药物溶出/Caco-2细胞 |
Advance on cell model for oral drug absorption |
| |
| JIANG Xue,XI Quan,ZHOU Jian-ping,JIN Fang. Advance on cell model for oral drug absorption[J]. WORLD CLINICAL DRUGS, 2012, 0(5): 292-297 |
| |
| Authors: | JIANG Xue XI Quan ZHOU Jian-ping JIN Fang |
| |
| Affiliation: | 1.Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009; 2.Shanghai Engineering Research Center of Respiratory Medicine,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437,China) |
| |
| Abstract: | Among various cell models as tools in oral drug absorption research,the most commonly used models are Caco-2 and MDCK cell including resent developed cell models,MDCK-MDR1,M cell,dissolution/Caco-2 system,HT-29 and TC7 cell.However,these cell models have some limitations.This review describes the specificity and application of various cell models. |
| |
| Keywords: | oral drug cell model Caco-2 cell MDCK cell M cell dissolution/Caco-2 system |
| 本文献已被 CNKI 等数据库收录！ |
|
