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| 脂联素与2型糖尿病血管病变的关系 | |
| 引用本文： | 姥勇,屈阳,朱旅云,李戈菲.脂联素与2型糖尿病血管病变的关系[J].新乡医学院学报,2011,28(1):89-91,94. |
| 作者姓名： | 姥勇 屈阳 朱旅云 李戈菲 |
| 作者单位： | 1. 武警医学院附属医院内分泌科,天津,300162 2. 武警医学院附属医院脑系科,天津,300162 3. 中国人民解放军白求恩国际和平医院内分泌科,河北,石家庄,050082 |
| 摘 要： | 目的探讨脂联素(ADPN)与2型糖尿病(T2DM)患者血管病变的关系以及在不同血管并发症发病机制中的作用。方法选取T2DM患者80例,根据血管并发症情况分为糖尿病大血管病变组、糖尿病微血管病变组和单纯糖尿病组。比较各组间体质量指数(BMI)、腰臀比(WHR)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)和ADPN等水平的差别,观察血浆ADPN与上述指标间的相关性。结果糖尿病大血管病变组中BMI和HbA1c水平均高于单纯糖尿病组(P<0.05);糖尿病大血管病变组中BMI、WHR及HbA1c水平均高于糖尿病微血管病变组(P<0.05);糖尿病微血管病变组中HbA1c水平高于单纯糖尿病组(P<0.05)。糖尿病大血管病变组ADPN水平低于糖尿病微血管病变组和单纯糖尿病组(P<0.05);糖尿病微血管病变组ADPN水平低于单纯糖尿病组(P<0.05)。多元回归分析显示:糖尿病大血管病变组HbA1c(r=-0.446,P<0.01)和BMI(r=-0.361,P<0.05)与ADPN水平负相关;糖尿病微血管病变组WHR与ADPN水平负相关(r=-0.451,P<0.01);单纯糖尿病组HDL-C与ADPN水平正相关(r=0.587,P<0.01)。结论血浆ADPN水平下降可作为预测T2DM患者发生血管并发症的指标。血浆ADPN水平与HDL-C正相关,对于防治T2DM患者血管并发症发生有积极作用。 |
| 关 键 词： | 2型糖尿病 脂联素 血管 血脂 |
Adiponectin and type 2 diabetes mellitus patients with vascular complications |
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| MU Yong,QU Yang,ZHU Lv-yun,LI Ge-fei.Adiponectin and type 2 diabetes mellitus patients with vascular complications[J].Journal of Xinxiang Medical College,2011,28(1):89-91,94. | |
| Authors: | MU Yong QU Yang ZHU Lv-yun LI Ge-fei |
| Institution: | 1 (1.Department of Endocrinology,the Affiliated Hospital of Medical College of Chinese People′s Armed Police Force,Tianjin 300162,China;2.Department of Neurosurgeon,the Affiliated Hospital of Medical College of Chinese People′s Armed Police Force,Tianjin 300162,China;3.Department of Endocrine,Bethune International Peace Hospital of Chinese People′s Liberation Army,Shijiazhuang 050082,Hebei Province,China) |
| Abstract: | Objective To observe the changes of plasma adiponectin(ADPN) in type 2 diabetes mellitus(T2DM) patients with vascular complications and to explore the roles of ADPN in the pathogenesis of different vascular complications.Methods Eighty patients with T2DM were selected and divided into diabetes macroangiopathy group,diabetes microangiopathy group and simple diabetes group based on the condition of vascular complications.The levels of body mass index(BMI),waist-hip ratio(WHR),total cholesterol(TC),triglycerci... |
| Keywords: | type 2 diabetes mellitus adiponectin blood vessel bloodfat |
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