Identification of Mycobacterium tuberculosis clinical isolates in Bangladesh by a species distinguishable multiplex PCR |
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| Authors: | Chie Nakajima Zeaur Rahim Yukari Fukushima Isamu Sugawara Adri GM van der Zanden Aki Tamaru Yasuhiko Suzuki |
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| Affiliation: | (1) Department of Global epidemiology, Hokkaido University Research Center for Zoonosis Control, Kita20-Nishi10, 001-0020 Kita-ku, Sapporo, Japan;(2) Tuberculosis laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), GPO Box 128, 1000 Dhaka, Bangladesh;(3) Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo, Japan;(4) Laboratory for Medical Microbiology and Public Health, P.O.Box 377, 7512 Burg. Edo Bergsmalaanl, AD Enschede, The Netherlands;(5) Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, 537-0025 Higashinari-ku, Osaka, Japan |
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| Abstract: | Background Species identification of isolates belonging to the Mycobacterium tuberculosis complex (MTC) seems to be important for the appropriate treatment of patients, since M. bovis is naturally resistant to a first line anti-tuberculosis (TB) drug, pyrazinamide, while most of the other MTC members are susceptible to this antimicrobial agent. A simple and low-cost differentiation method was needed in higher TB burden countries, such as Bangladesh, where the prevalence of M. bovis among people or cattle has not been investigated. |
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