| 正交试验优选苦参生物碱提取工艺研究 |
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| 引用本文： | 王丹,吕佳,张振秋,赵琳. 正交试验优选苦参生物碱提取工艺研究[J]. 中国中医药信息杂志, 2011, 18(1): 51-52. DOI: 10.3969/j.issn.1005-5304.2011.01.020 |
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| 作者姓名： | 王丹 吕佳 张振秋 赵琳 |
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| 作者单位： | 辽宁中医药大学药学院,辽宁,大连,116600 |
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| 基金项目： | 大连市科技局科学技术基金(2008J21JH007) |
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| 摘 要： | 目的优选苦参中生物碱的提取工艺。方法采用正交试验，以苦参中苦参碱和氧化苦参碱提取总量为考察指标。结果最佳提取工艺条件是：以60％乙醇为溶媒，加醇量为12、10、10倍，提取3次，每次2h。结论优选得到的工艺稳定可行，适合工业大生产。
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| 关 键 词： | 苦参 苦参生物碱 氧化苦参碱 苦参碱 提取工艺 正交试验 |
Orthogonal Optimization of Extraction Process of Sophora Alkaloid |
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| WANG Dan,LV Jia,ZHANG Zhen-qiu,ZHAO Lin. Orthogonal Optimization of Extraction Process of Sophora Alkaloid[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2011, 18(1): 51-52. DOI: 10.3969/j.issn.1005-5304.2011.01.020 |
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| Authors: | WANG Dan LV Jia ZHANG Zhen-qiu ZHAO Lin |
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| Affiliation: | WANG Dan,LV Jia,ZHANG Zhen-qiu,ZHAO Lin(Pharmacy College,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China) |
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| Abstract: | Objective To optimize the extraction process of Sophora alkaloids in Sophora flavescens Ait.by orthogonal design.Methods The optimum extraction condition was investigated by orthogonal design and the extraction quantity of matrine and oxymatrine was regarded as the investigated index.Results The optimal extraction process was as follows:refluxing herbs for 3 times with 12,10,10 times of 60% alcohol,two hours for each time.Conclusion The optimized process is stable and suitable for industrial manufacture. |
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| Keywords: | Sophora flavescens Ait. Sophora alkaloid oxymatrine matrine extraction process orthogonal experiment |
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