Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases |
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| Authors: | Koichi Fujimoto Shinobu Ikeda Tomio Arai Noriko Tanaka Toshio Kumasaka Takeo Ishii Kozui Kida Masaaki Muramatsu Motoji Sawabe |
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| Institution: | 1.Department of Molecular Epidemiology, Medical Research Institute,Tokyo Medical and Dental University,Chiyoda-ku, Tokyo,Japan;2.Department of Pathology,Tokyo Metropolitan Geriatric Hospital,Itabashi-ku, Tokyo,Japan;3.Department of Biostatistics,Harvard School of Public Health,Boston,USA;4.Department of Pathology,Juntendo University School of Medicine,2-1-1 Hongo, Bunkyo-ku,Tokyo,Japan;5.Department of Pulmonary Medicine, Infection and Oncology,Nippon Medical School,Tokyo,Japan |
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| Abstract: | Background The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease
(COPD) and related phenotypes. Whether they are associated with emphysema is not known. |
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