Identification of an N-terminal 27 kDa fragment of <Emphasis Type="Italic">Mycoplasma pneumoniae</Emphasis> P116 protein as specific immunogen in <Emphasis Type="Italic">M. pneumoniae</Emphasis>infections

Background  

Mycoplasma pneumoniae is an important cause of respiratory tract infection and is increasingly being associated with other diseases such as asthma and extra-pulmonary complications. Considerable cross-reactivity is known to exist between the whole cell antigens used in the commercial serological testing assays. Identification of specific antigens is important to eliminate the risk of cross-reactions among different related organisms. Adherence of M. pneumoniae to human epithelial cells is mediated through a well defined apical organelle to which a number of proteins such as P1, P30, P116 and HMW1-3 have been localized, and are being investigated for adhesion, gliding and immunodiagnostic purposes.