| 桑白皮水提取液的耐缺氧作用 |
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| 引用本文： | 曾靖,叶和杨,赖飞,黄贤华,朱遵平.桑白皮水提取液的耐缺氧作用[J].中国组织工程研究与临床康复,2003,7(27):3692-3693. |
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| 作者姓名： | 曾靖 叶和杨 赖飞 黄贤华 朱遵平 |
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| 作者单位： | 赣南医学院药理教研室,江西省赣州市,341000 |
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| 摘 要： | 目的:研究桑白皮水提取液对小鼠耐缺氧作用的影响。方法:①小鼠(n=40)腹腔注射500g/L的桑白皮水提取液(0.01mL/g,0.02mL/g),15min后,将小鼠分别放入250mL的磨口广口瓶内密封,以最后一次呼吸为指标,观察小鼠存活时间。②小鼠(n=30)腹腔注射500g/L的桑白皮水提取液(0.01mL/g,0.02mL/g),15min后,不需麻醉,用剪刀在耳下部快速断头,记录喘气时间。③小鼠随机分为3组,每组12只,对照组按0.03mL/g剂量给小鼠皮下注射生理盐水,5min后按0.02mL/g剂量给小鼠腹腔注射生理盐水;模型组按0.015mg/g的剂量给小鼠皮下注射异丙肾上腺素,5min后按0.02mL/g剂量给小鼠腹腔注射生理盐水。给药组按0.015mg/g剂量给小鼠皮下注射异丙肾上腺素,5min后腹腔注射桑白皮水提取液。给药后10min,分别放入广口瓶内密封,记录小鼠存活时间。结果:①500g/L桑白皮水提取液(0.01mL/g,0.02mL/g)能非常显著延长常压耐缺氧条件下小鼠的存活时间犤(66.4±8.9)min,(90.3±7.4)min犦,与对照组犤(36.2±4.3)min犦比较差异有显著性意义(t=3.358,3.617;P均<0.01)。②对断头小鼠的呼吸时间犤(21.2±0.8)s,(23.5±0.7)s犦有显著延长作用(t=2.824,3.432;P<0.05,P<0.01)。③模型组和给药组小鼠在常压缺氧条件下的生存时间犤(27.9±2.6)min,(50.6±3.4)min犦
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| 关 键 词： | 桑白皮 低氧 小鼠 |
| 文章编号： | 1671-5926(2003)27-3692-02 |
| 修稿时间： | 2003年6月23日 |
The antihypoxia effect of Morus alba L. water extract |
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| Jing Zeng,He-Yang Ye,Fei Lai,Xian-Hua Huang,Zun-Ping Zhu,Departmen t of Pharmacology,Gannan Medical College,Ganzhou ,Jiangxi Province,China.The antihypoxia effect of Morus alba L. water extract[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2003,7(27):3692-3693. |
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| Authors: | Jing Zeng He-Yang Ye Fei Lai Xian-Hua Huang Zun-Ping Zhu Departmen t of Pharmacology Gannan Medical College Ganzhou Jiangxi Province China |
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| Institution: | Jing Zeng,He-Yang Ye,Fei Lai,Xian-Hua Huang,Zun-Ping Zhu,Departmen t of Pharmacology,Gannan Medical College,Ganzhou 341000,Jiangxi Province,China |
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| Abstract: | |
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| Keywords: | S:MAL water extract has the obvious effect of antihypoxia |
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