Impact of a Deep Learning Model for Predicting Mammographic Breast Density in Routine Clinical Practice |
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Institution: | 1. Quality and Safety Office, Division of Breast Imaging, Massachusetts General Hospital, Boston, Massachusetts;2. Harvard Medical School, Boston, Massachusetts;3. Massachusetts General Hospital, Boston, Massachusetts;4. Department of Medical Epidemiology and Biostatistics, Karolinska Intitutet, Solnavagen, Sweden;5. Newton-Wellesley Hospital, Newton, Massachusetts;6. Chief, Division of Breast Imaging, Massachusetts General Hospital, Boston, Massachusetts |
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Abstract: | ObjectiveLegislation in 38 states requires patient notification of dense mammographic breast tissue because increased density is a marker of breast cancer risk and can limit mammographic sensitivity. Because radiologist density assessments vary widely, our objective was to implement and measure the impact of a deep learning (DL) model on mammographic breast density assessments in clinical practice.MethodsThis institutional review board–approved prospective study identified consecutive screening mammograms performed across three clinical sites over two periods: 2017 period (January 1, 2017, through September 30, 2017) and 2019 period (January 1, 2019, through September 30, 2019). The DL model was implemented at sites A (academic practice) and B (community practice) in 2018 for all screening mammograms. Site C (community practice) was never exposed to the DL model. Prospective densities were evaluated, and multivariable logistic regression models evaluated the odds of a dense mammogram classification as a function of time and site.ResultsWe identified 85,124 consecutive screening mammograms across the three sites. Across time intervals, odds of a dense classification decreased at sites exposed to the DL model, site A (adjusted odds ratio aOR], 0.93; 95% confidence interval CI], 0.86-0.99; P = .024) and site B (aOR, 0.81 95% CI, 0.70-0.93]; P = .003), and odds increased at the site unexposed to the model (site C) (aOR, 1.13 95% CI, 1.01-1.27]; P = .033).DiscussionA DL model reduces the odds of screening mammograms categorized as dense. Accurate density assessments could help health care systems more appropriately use limited supplemental screening resources and help better inform traditional clinical risk models. |
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Keywords: | Breast density risk assessment screening mammography |
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