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Germline Cancer Susceptibility Gene Testing in Unselected Patients With Colorectal Adenocarcinoma: A Multicenter Prospective Study

Institution:	1. Division of Hematology and Medical Oncology;3. Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Jacksonville, Florida;4. Department of Clinical Genomics, Mayo Clinic;6. Center for Individualized Medicine, Mayo Clinic;5. Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota;7. Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada;12. Department of Health Services Research, Mayo Clinic, Phoenix, Arizona;8. Invitae, San Francisco, California;10. Division of Hematology and Medical Oncology, Department of Medicine, Mayo Clinic, Jacksonville, Florida

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Keywords:	Colorectal Cancer Germline Testing Lynch Syndrome Homologous Recombination Deficiency CRC"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"colorectal cancer FVT"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"family variant testing HRD"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"homologous recombination deficiency INTERCEPT"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"Interrogating Cancer using Proactive genetic Testing MMR"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"mismatch repair NCCN"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"National Comprehensive Cancer Network NGS"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"next-generation sequencing OR"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"odds ratio OS"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"overall survival PARP"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"poly-adenosine diphosphate ribose polymerase PGV"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"pathogenic germline variant VUS"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"variant of unknown significance
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