Amplification and overexpression of c-met gene in Epstein-Barr virus-associated gastric carcinomas. |
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Authors: | Yuko Kijima Shuichi Hokita Heiji Yoshinaka Tetsuhiko Itoh Chihaya Koriyama Yoshita Eizuru Suminori Akiba Takashi Aikou |
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Affiliation: | First Department of Surgery, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, Japan. ryu23@gf6.so-net.ne.jp |
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Abstract: | To reveal the role of oncogenes in Epstein-Barr virus (EBV)-positive gastric carcinomas, the amplification and overexpression of the c-met gene were examined by a competitive polymerase chain reaction and immunohistochemistry, respectively. The proportion of c-met amplification and overexpression in EBV-positive and -negative carcinomas did not differ significantly. The amplification and overexpression of the c-met gene in EBV-negative gastric carcinomas were significantly associated with upper location, deeper invasion and lymphatic invasion, while in EBV-positive gastric carcinomas a significant correlation with c-met activation was observed only in deeper invasion. However, none of the observed associations of c-met amplification or overexpression with clinicopathological features in the EBV-positive and -negative carcinomas differed significantly in their strength or direction. These results suggest that the amplification and overexpression of c-met gene do not play a different role in the progression and metastasis of EBV-positive and EBV-negative gastric carcinomas. |
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