支气管哮喘与睡眠呼吸紊乱的关系

目的探讨支气管哮喘与睡眠呼吸紊乱的关系，提出可行性治疗策略。方法对136例支气管哮喘患者进行睡眠问卷调查及夜间血氧饱和度监测，睡眠问卷包括是否打鼾及白天嗜睡情况（爱波沃斯评分，ESS），夜间动态血氧监测指标包括氧减饱和指数（ODI4）、最低血氧饱和度（LSaO2）、平均血氧饱和度（MSaO2）、血氧饱和度低于90％的时间占睡眠总时间的百分比（SIT90％）。结果45．6％（62／136）的哮喘患者ODI4≥5次／小时，19．1％（26／136）的哮喘患者ODI4≥10次／小时，8．8％（12／136）的哮喘患者ODI4≥15次／lh时，SIT90％≥5％者占49．3％（67／136），SIT90％≥10％者占37．5％（51／136），SIT90％≥15％者占27．9％（38／136）。维族与汉族哮喘患者间体质量指数（BMI），SIT90％及FEV1％比较差异有统计学意义（P〈0．05）。结论汉族与维族哮喘患者中睡眠呼吸紊乱的患病率均较高，且普遍存在夜间低氧现象，维族低于汉族，夜间持续正压通气治疗可能是控制夜间哮喘的重要治疗方法。

Relationship between sleep-disorder breathing and bronchial asthma

Objective To Study the relationship of sleep-disorder breathing and bronchial asthma in Sleep. to provide data for treatment and prevention of this disorder. Methods 136 patients with stable asthma were under home pulse oximeter testing, all subjects were asked at home to answer questions about their snoring by himself or bed partner. They were asked to answer the questions from a question concerning snoring, daytime sleepness （Epworth sleep scale）, from overnight pulse oximetry, the percentage of time spent at SaO2 below 90% （SIT90 % ）, mean SaO2 （MSaO= % ）, the lowest SaO2 （LSaO2%）and the number of desaturations≥4% per hour（ ODI4 ） were calculated. Result The prevalence of snoring in asthma was 61.4% , the prevalence of sleep-disorder breathing in asthma is repective 45.6% , 19.1% and 8.8% , by criteria of ODI4 ≥5 /h,ODI4 ≥10次/ h and ODI4≥15次/h. The prevalence of nocturnal desaturation in asthma is repective 49. 3% , 37. 5% and 27.9% , by criteria SIT90% ≥ 5% , SIT90%≥10%, and SIT90 % ≥ 15%. There are significant difference on body mass index, SIT90, and FEV1% between asthma of Han nationality and Uygur nationality （ P 〈 0.05 ）. Conclusion Sleep-disorder breathing and nocturnal desaturation in asthma of ttan nationality and Uygur nationality patients are common, especially in Uygur nationality, nocturnal desaturation of bronchial asthma in sleep needs better understanding and study. The important treatment of asthma Including positive airway pressure therapies.