国产吉西他滨联合顺铂治疗晚期卵巢癌的临床研究

目的:探讨国产吉西他滨(泽菲)联合顺铂治疗晚期卵巢癌的疗效及毒性反应。方法:泽菲1000mg/m2静脉滴注超过30分钟,第1、8天,顺铂30mg/m2静脉滴注超过3小时,第1~3天,化疗前30分钟推注康泉预防消化道反应,每2天重复1次,至少2疗程,治疗至疾病进展或出现不能接受的毒性反应,最多6疗程,每2疗程后评价疗效,复查包括妇科检查、胸腹CT、血CA125。随访30个月。结果:31例转移性卵巢癌共完成疗程数为123个,每个患者接受治疗2~6个疗程,平均4个疗程,随访率100%,获得CR2例,PR13例,有效率48·39%,生存质量明显提高。结论:泽菲联合顺铂对于晚期卵巢癌患者是有效的,毒性反应可以耐受,值得临床进一步研究。

Gemcitabine plus cisplatin treatment for 31 cases with advanced ovarian cancer

Objective:To evaluate the efficacy and toxicity of a combination of gemcitabine and cisplatin in advanced ovarian cancer cases.Methods:31 cases of pathologically comfirmed advanced ovarian cancer were treated with combined chemotherapy including gemcitabine plus cisplatin. The treatment period included GEM 1.0g/m~2 in day 1,8;PDD 30mg/m~2 in day 1,2,3. Each cycle lasted for 21 days.Results:Out of 31 evaluable patients, 2 achieved complete response, 13 achieved partial response, objective response' rate was 48.39%. Median progression-free interval was 8.68 months for the entire study group. Median survival was 15.58 months. The side effects were mainly myleosuppression and digestive tract reaction.Conclusion:Gemcitabine combined with cisplatin is effective, its toxicity is well tolerated in the advanced ovarian cancer.