| LOX-1研究进展 |
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| 引用本文： | 李玉娟,杜冠华. LOX-1研究进展[J]. 中国药理学通报, 2003, 19(3): 245-248 |
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| 作者姓名： | 李玉娟 杜冠华 |
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| 作者单位： | 中国医学科学院·中国协和医科大学药物研究所,北京,100050 |
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| 基金项目： | 国家高技术研究发展计划 (863 )项目资助课题No2 0 0 1AA2 3 40 21，国家自然科学基金资助课题 No 3 0 0 1161940 |
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| 摘 要： | LOX 1是一种Ⅱ型膜蛋白 ,按结构分类 ,它属于C型选择素家族。它可以结合、中和、降解ox LDL ,还具有介导血小板与内皮细胞的相互作用等功能。LOX 1的表达不是结构性的 ,在血管紧张素Ⅱ、剪切力、肿瘤坏死因子α、肿瘤生长因子β、内皮素 1作用下 ,其表达上调。对血浆中可溶性LOX 1的检测有助于评价AS及心血管疾病的进展
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| 关 键 词： | LOX1 氧化性低密度脂蛋白 动脉粥样硬化 |
| 文章编号： | 1001-1978(2003)03-0245-04 |
| 修稿时间： | 2002-07-19 |
The progress in LOX-1 research |
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| LI Yu Juan,DU Guan Hua. The progress in LOX-1 research[J]. Chinese Pharmacological Bulletin, 2003, 19(3): 245-248 |
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| Authors: | LI Yu Juan DU Guan Hua |
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| Abstract: | Lectin like oxidized low density lipoprotein receptor 1(LOX 1) is a type Ⅱ membrane protein belonging to the C type lectin family molecules which can act as a cell surface endocytosis receptor for oxidized LDL.LOX 1 can support binding, internalization and proteolytic degradation of oxidized LDL. And LOX 1 is involved in the platelet endothelium interaction and mediates phagocytosis of aged/apoptotic cells in endothelial cells ox LDL. Purification of soluble LOX 1 and the N terminal amino acid sequencing identified the two cleavage sites (Arg 86 Ser 87 and Lys 89 Ser 90 ). LOX 1 expression is not constitutive, but can be induced by proinflammatory stimuli, such as Angiotension Ⅱ, fluid shear stress and so on. |
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| Keywords: | LOX 1 ox LDL atherosclerosis |
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