Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: Clinical and pathophysiological implications |
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Authors: | J. E. Hodler R. L. Galeazzi B. Frey M. Rudhardt A. J. Seiler |
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Affiliation: | (1) Medizinische Poliklinik und Medizinische Klinik der Universität Bern and policlinique médicale, Université de Genève, Bern and Geneva, Switzerland |
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Abstract: | Summary The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65±0.4 h, the total clearance amounting to 70.1±19.2 ml/min. Peritoneal clearance was calculated to be 6.9±1 ml/min. After peritoneal instillation, the bioavailability was 63.9±5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients. |
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Keywords: | cefoperazone peritoneal dialysis pharmacokinetics terminal renal failure peritonitis |
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