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Cardiac sensitization induced by phenobarbitone and prolonged by CS2 |
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| Authors: | Ian Eastwood Philip J. Forshaw Jeyarajah Jeyeratnam Laszlo Magos |
| Affiliation: | (1) Toxicology Unit, Medical Research Council Laboratories, SM5 4EF Carshalton, Surrey, Great Britain;(2) Present address: Martin-Hamblin Research, Cavendish Square, W1 London, Great Britain;(3) Present address: Department of Public Health and Preventive Medicine, Faculty of Medicine, University of Sri Lanka, 8 Colombo, Sri Lanka |
| Abstract: | The arrhythmogenic effect of 8  g/kg noradrenaline given i.v. was increased in male rats pretreated 1–2 day s earlier with phenobarbitone and starved from the time of the first phenobarbitone injection (80 mg/kg followed by 50 mg/kg 6 h later). Daily exposure to 4.0 mg/l CS2 (first exposure 24 h after the first phenobarbitone injection) for 4 h prevented the decline in susceptibility on the 3rd and 4th days after phenobarbitone, when the reaction of unexposed rats to noradrenaline returned to normal. |
| Keywords: | Cardiac sensitization Noradrenaline Phenobarbitone Carbon disulphide |
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