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| 儿童急性淋巴细胞白血病治疗中甲氨蝶呤血药浓度与不良反应的相关性研究 | |
| 引用本文： | 窦云,徐为人,李泽辉.儿童急性淋巴细胞白血病治疗中甲氨蝶呤血药浓度与不良反应的相关性研究[J].药学服务与研究,2008,8(3):177-180. |
| 作者姓名： | 窦云 徐为人 李泽辉 |
| 作者单位： | 1. 中国医学科学院北京协和医学院血液学研究所血液病医院药剂科,天津,300020;天津医科大学基础医学院药理学教研室,天津,300070 2. 天津药物研究院新药设计与发现重点实验室,天津,300193 3. 中国医学科学院北京协和医学院血液学研究所血液病医院药剂科,天津,300020 |
| 摘 要： | 目的：研究急性淋巴细胞白血病（ALL）患儿应用大剂量甲氨蝶呤（MTX）化疗期间，MTX血药浓度与不良反应的关系，从而设定合理的MTX解救方案。方法：133例ALL标危患儿连续静脉滴注MTX 24h后，监测48h时MTX血药浓度（C48h），并观察毒副作用。结果和结论：MTX C48h≤0．1μmol／L是一个比较安全的浓度范围，在充分水化、碱化的同时，在MTX C48h为0．3μmol／L左右时停止解救，在临床上仍然是安全的。 |
| 关 键 词： | 白血病 淋巴细胞 急性 儿童 甲氨蝶呤 血药浓度 药物副反应报告系统 亚叶酸钙 |
The relationship between serum concentration of methotrexate and adverse drug reactions in children with acute lymphoblastic leukemia |
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| DOU Yun,XU Wei-ren,LI Ze-hui.The relationship between serum concentration of methotrexate and adverse drug reactions in children with acute lymphoblastic leukemia[J].Pharmaceutical Care and Research,2008,8(3):177-180. | |
| Authors: | DOU Yun XU Wei-ren LI Ze-hui |
| Institution: | DOU Yun ,XU Wei-ren, LI Ze-hui (1. Department of Pharmacy,Blood Diseases Hospital, Institute of Hematology, Chinese Academy of Medical Science ＆ Peking Union Medical College, Tianjin 300020 ,China; 2. Department of Pharmacology, Faculty of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; 3. Key Laboratory of Drug Research, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China) |
| Abstract: | Objective： To study the relationship between serum concentration of methotrexate（MTX） and adverse reactions during high-dose methotrexate（HD-MTX） treatment in children with acute lymphoblaslie leukemia（ALL）, in order to adjust the rescue dose of calcium folinatc. Methods： One hundred and thirty three children with ALL of standard risk received HD-MTX treatment. After continuous intravenous infusion of MTX for 24 h, the serum concentration of MTX at 48 h was determined, and the adverse reactions were recorded. Results and conclusion： MTX is safe for patients when serum concentration of MTX at 48 h is less than 0. 1 μmol/L. With sufficient hydration and alkalinization, it is safe to halt rescue when serum concentration of MTX at 48 h is about 0. 3μmol/L |
| Keywords: | leukemia lymphocytic acute child methotrexate plasma concentration adverse drug reaction reporting systems calcium folinate |
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