Possible use of repeated cold stress for reducing fatigue in Chronic Fatigue Syndrome: a hypothesis |
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Authors: | Nikolai A Shevchuk |
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Institution: | (1) Molecular Radiobiology Section, the Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401 College St, Richmond, VA 23298, USA |
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Abstract: | Background Physiological fatigue can be defined as a reduction in the force output and/or energy-generating capacity of skeletal muscle
after exertion, which may manifest itself as an inability to continue exercise or usual activities at the same intensity.
A typical example of a fatigue-related disorder is chronic fatigue syndrome (CFS), a disabling condition of unknown etiology
and with uncertain therapeutic options. Recent advances in elucidating pathophysiology of this disorder revealed hypofunction
of the hypothalamic-pituitary-adrenal axis and that fatigue in CFS patients appears to be associated with reduced motor neurotransmission
in the central nervous system (CNS) and to a smaller extent with increased fatigability of skeletal muscle. There is also
some limited evidence that CFS patients may have excessive serotonergic activity in the brain and low opioid tone. |
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