Paradoxical antiproliferative effect by a murine mammary tumor-derived epithelial cell line |
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| Authors: | Esteban N Gurzov Sanaa M Nabha Hamilto Yamamoto Hong Meng O Graciela Scharovsky R Daniel Bonfil |
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| Affiliation: | 1.Department of Molecular Biology,Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid, Facultad de Ciencias,Madrid,Spain;2.Departments of Urology and Pathology,Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute,Detroit,USA;3.Instituto de Genética Experimental, School of Medical Sciences,University of Rosario,Rosario,Argentina |
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| Abstract: | Background Despite significant advancement in breast cancer therapy, there is a great need for a better understanding of the mechanisms involved in breast carcinogenesis and progression, as well as of the role of epigenetic contributions from stromal cells in mammary tumorigenesis. In this study, we isolated and characterized murine mammary tumor-derived epithelial and myofibroblast cell lines, and investigated the in vitro and in vivo effect of cellular soluble factors produced by the epithelial cell line on tumor cells. |
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