Salidroside suppresses group 2 innate lymphoid cell-mediated allergic airway inflammation by targeting IL-33/ST2 axis |
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| Institution: | 1. Department of Food, Shanghai Business School, Shanghai 200235, PR China;2. Department of Chemistry, School of Sciences, Shanghai University, Shanghai 200444, PR China;3. School of Public Health, Shanghai Aurora College, Shanghai 201908, PR China;1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi''an, China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Parmaceutical Co. Ltd., Lianyungang, China;1. Defence Institute of High Altitude Research, DRDO, C/o 56 APO, Leh-Ladakh, Jammu & Kashmir Pin- 901205, India;2. Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, India;3. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India;4. Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India |
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| Abstract: | Salidroside, an active component extracted from Rhodiola rosea, has been reported to inhibit allergic asthma. However, its mechanism has not been fully elucidated. Group 2 innate lymphoid cells (ILC2s) accumulate in the lung and cooperate with other cells to drive type 2 inflammation stimulated by inhaled allergens. The study aims to explore the suppressive effect of salidroside on ILC2s and IL-33/IL-33R (ST2) axis in allergic airway inflammation. The ovalbumin (OVA)-sensitized/challenged mice were established. Airway eosinophil recruitment, increased total IgE in the serum and type 2 cytokines IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluids and lung tissues were identified in the OVA-induced mice model, all of which were inhibited by pretreatment with different doses of salidroside. Moreover, salidroside suppressed lung total ILC2 and ST2-expressing ILC2 accumulation, lung IL-33 and ST2 expressions in mice. In vitro, OVA could induce IL-33 expression in BEAS-2B cells, which was also effectively inhibited by salidroside. This study firstly reveals salidroside as a potential therapeutic drug for allergic asthma by inhibiting ILC2-mediated airway inflammation via targeting IL-33/ST2 axis. |
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| Keywords: | Salidroside Airway inflammation Asthma Group 2 innate lymphoid cell IL-33 ST2 |
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