IL-6基因多态性与短暂性脑缺血发作的关系

目的:研究IL-6基因启动子区域 (-174)位点G/C碱基多态性与短暂性脑缺血发作（TIA）的发病率及其临床进程之间的关系。方法:临床确诊的121例TIA患者和114例同年龄段、同性别组成的健康对照者，采血并用MS-PCR法对基因型进行检测，随访3个月，记载3个月内进展为脑梗塞的情况。结果:TIA患者的GG型基因比例（54.6%）明显高于对照组（38.6%）(P<0.05)，也明显高于其他两型（GC 30.6%，CC 14.9%）(P<0.05)。GG型患者66例，3个月内发展为脑梗塞者28例（42.4%），与GC型(16.2%，6/37)、CC型（16.7%，3/18）相比，差异有显著性（P<0.05)。结论:IL-6基因启动子区域GG型与TIA的发病及预后有明显的相关性。

Association between polymorphism of IL-6 gene and TIA

Objective To investigate the statistical association between the G/C promoter polymorphism at(-174) of the IL-6 gene and transient ischemia attack(TIA) events,as well as the progress of cerebral infarction in(3 months.)Methods 121 TIA patients and 114 age-and sex-matched healthy control subjects were examined for the(-174) IL-6 G/C polymorphism by mutagenic separated polymerase chain reaction(MS-PCR).The progress of cerebral infarction in 3 months was recorded.Results In the patients with TIA,the pro-portion of genotype GG(54.6%)was significantly higher than that in the control group(38.6%)(P<0.05),and also higher than those of GC(30.6%) and CC(14.9%)(P<0.05).The incidence rate of cerebral infarction in 3 months had significant differences between GG patients(28/66,54.6%) and GC(6/37,16.2%),CC(3/18,16.7%)(P<0.05).Conclusion The genotype GG of IL-6 promoter is associated with pathogenesis and prognosis of TIA.