非阿片类药物改善阿片类药物致呼吸抑制研究进展

阿片类药物通过作用于阿片受体,激活与受体偶联的G蛋白和(或)β-抑制蛋白等信号通路而发挥镇痛和麻醉等效应,但同时阿片类药物致呼吸抑制(OIRD)则是临床常见的严重问题.目前通常采用阿片受体拮抗剂纳洛酮等改善OIRD,但纳洛酮可能会拮抗阿片类药物的镇痛作用,甚至带来许多不可预知的不良反应.近年来,使用非阿片类药物直接和(...

Research progress in improvement of opioid-induced respiratory depression by non-opioid drugs

Opioid drugs activate G protein and(or)β-arrestin protein signaling pathways by acting on opioid receptors,which can generate analgesia and anesthesia effects,but at the same time,opioidinduced respiratory depression(OIRD)is a common severe clinical problem.Currently,naloxone,an opioid receptor antagonist,is usually used to improve respiratory depression,but naloxone may counteract the analgesic effect and even induce many unpredictable adverse reactions.In recent years,non-opioid drugs have been used to directly or indirectly regulate the respiratory center to improve OIRD without affecting analgesia,which is becoming a new area of research.This paper reviewed such non-opioid drugs as theα-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor modulator,5-hydroxytryptamine receptor agonist,phosphodiesterase-4 inhibitor,glial cell inhibitor,nicotinic acetylcholine receptor agonist,potassium ion channel blocker and other non-opioid drugs that have been much reported in recent years.