Intratemporal facial nerve ultrastructure in patients with idiopathic facial paralysis. Viral infection evidence study |
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| Authors: | Rosangela Aló Maluza Florez Raquel Lang Adriano Mora Veridiano Renato de Oliveira Zanini Pedro Luiz Calió Ricardo dos Santos Simões José Ricardo Gurgel Testa |
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| Affiliation: | 1. MSc in Otolaryngology - Federal University of São Paulo (UNIFESP), Full Professor - Universidade Santa Cecília (UNISANTA) Coordinator of the Dentistry School of UNISANTA;2. DDS - UNISANTA, Professor at the Dentistry School - UNISANTA;3. MSc in morphology - UNIFESP, Assistant Professor - Dentistry School - UNISANTA;4. DDS - UNISANTA, Professor at the Dentistry School - UNISANTA;5. PhD in Histology and Structural Biology - UNIFESP, Full Professor of Dentistry - UNISANTA;6. OBGYN (TEGO), MSc Student - University of São Paulo;7. PhD in Otolaryngology - UNIFESP, Adjunct Professor of ENT - UNIFESP. Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Universidade Federal de São Paulo (UNIFESP/EPM) |
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| Abstract: | The etiology of idiopathic peripheral facial palsy (IPFP) is still uncertain; however, some authors suggest the possibility of a viral infection.Aimto analyze the ultrastructure of the facial nerve seeking viral evidences that might provide etiological data.Material and MethodsWe studied 20 patients with peripheral facial palsy (PFP), with moderate to severe FP, of both genders, between 18-60 years of age, from the Clinic of Facial Nerve Disorders. The patients were broken down into two groups - Study: eleven patients with IPFP and Control: nine patients with trauma or tumor-related PFP. The fragments were obtained from the facial nerve sheath or from fragments of its stumps - which would be discarded or sent to pathology exam during the facial nerve repair surgery. The removed tissue was fixed in 2% glutaraldehyde, and studied under Electronic Transmission Microscopy.ResultsIn the study group we observed an intense repair cellular activity by increased collagen fibers, fibroblasts containing developed organelles, free of viral particles. In the control group this repair activity was not evident, but no viral particles were observed.ConclusionThere were no viral particles, and there were evidences of intense activity of repair or viral infection. |
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| Keywords: | facial paralysis facial nerve facial nerve diseases bell palsy. |
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