Association study of fatty acid binding protein 2 gene polymorphism for diabetic nephropathy in Japanese patients with type 2 diabetes |
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| Authors: | Keiji Yoshioka Toshihide Yoshida Akinori Kogure Yasuto Takakura Tsunekazu Umekawa Hitoshi Toda |
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| Affiliation: | 1. Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi, Japan;2. Department of Daibetes and Metabolism, Kyoto City Hospital, Kyoto, Japan;3. Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan;4. Department of Internal Medicine, Kyoto Second Red Cross Hospital, Kyoto, Japan;5. Umekawa Clinic, Kyoto, Japan;6. Sakazaki Clinic, Kyoto, Japan |
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| Abstract: | To test the hypothesis whether the Ala54Thr polymorphism of the fatty acid binding protein 2 (FABP2) gene was associated with diabetic nephropathy, we studied a total of 397 Japanese type 2 diabetic patients. The diagnosis of diabetic nephropathy was based on measurements of urinary albumin:creatinine ratio (ACR). We subdivided subjects as those with normoalbuminuria (ACR < 30 mg/g Cr), those with micro- albuminuria (ACR:30–300 mg/g Cr), and those with macroalbuminuria (ACR 3300 mg/g Cr). FABP2 genotypes were determined with a fluorescent allele-specific DNA primer assay system. The results showed that the genotypes of Ala54Thr polymorphism of the FABP2 gene were not significantly different among normo-, micro- and macro-albuminuria groups, suggesting that polymorphism of this gene was not associated with diabetic nephropathy in Japanese type 2 diabetic subjects. |
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