血清Eotaxin-1和CCP抗体水平与类风湿关节炎疾病活动度的关系研究

目的研究类风湿关节炎疾病活动度与血清嗜酸性粒细胞趋化因子1(Eotaxin-1)和抗环胍氨酸肽(CCP)抗体水平的关系。方法回顾性选取2019年10月至2020年10月上海同济大学附属杨浦医院收治的类风湿关节炎患者50例,作为研究组;另选取同期该院非类风湿关节炎患者50例作为对照1组,健康体检人员50例作为对照2组。统计分析3组人员血清Eotaxin-1、抗CCP抗体水平,血清Eotaxin-1、抗CCP抗体阳性情况,观察血清Eotaxin-1、抗CCP抗体水平与研究组患者疾病活动度的相关性。结果研究组患者的血清Eotaxin-1、抗CCP抗体水平(95.9±16.5)pg/mL、(114.8±24.4)RU/mL]均显著高于对照1组(80.2±12.6)pg/mL、(35.7±5.3)RU/mL]、对照2组(79.0±12.3)pg/mL、(13.9±2.1)RU/mL],差异均有统计学意义(P<0.05),对照1组患者的血清抗CCP抗体水平显著高于对照2组,差异有统计学意义(P<0.05),但对照1组和对照2组人员的血清Eotaxin-1水平之间的差异无统计学意义(P>0.05)。研究组患者的血清Eotaxin-1、抗CCP抗体阳性率(24.0%、68.0%)均显著高于对照1组(4.0%、20.0%)、对照2组(0、0),差异有统计学意义(P<0.05),对照1组患者的血清抗CCP抗体阳性率显著高于对照2组,差异有统计学意义(P<0.05),但对照1组和对照2组人员的血清Eotaxin-1阳性率之间的差异无统计学意义(P>0.05)。研究组患者血清Eotaxin-1、抗CCP抗体水平与压痛关节数(TJC)、28处关节活动度(DAS28)均呈显著的正相关关系(P<0.05),血清Eotaxin-1水平与肿胀关节数(SJC)呈显著的正相关关系(P<0.05),但血清抗CCP抗体水平与SJC之间无明显相关性(P>0.05)。结论血清Eotaxin-1和CCP抗体水平与类风湿关节炎患者疾病活动度关系密切。

Study of relationship between eotaxin-1,CCP antibody and rheumatoid arthritis activity

Objective To study the relationship between the disease activity of rheumatoid arthritis and serum eosinophil chemotactic factor 1(eotaxin-1)and anticyclic citrullinated peptide(CCP)antibody.Methods From October 2019 to October 2020,50 cases of patients with rheumatoid arthritis in Tongji University Affiliated to Yangpu Hospital were retrospectively selected as study group,and 50 cases of patients with non rheumatoid arthritis in the same period were selected as control group 1,and 50 cases of healthy persons in the same period were selected as control group 2.The serum eotaxin-1,anti CCP antibody levels,serum eotaxin-1 and anti CCP antibody positives of the three groups were statistically analyzed,correlations between serum eotaxin-1,anti CCP antibody level and disease activity of patients in the study groups were observed.Results The levels of serum eotaxin-1 and anti CCP antibody in the study group(95.9±16.5)pg/mL,(114.8±24.4)RU/mL]were significantly higher than the control group 1(80.2±12.6)pg/mL,(35.7±5.3)RU/mL]and 2(79.0±12.3)pg/mL,(13.9±2.1)RU/mL],the differences were statistically significant(P<0.05),the serum anti CCP antibody level in the control group 1 was significantly higher than the control group 2,the difference was statistically significant(P<0.05),but the difference of serum eotaxin-1 level between the control group 1 and the control group 2 was not significant(P>0.05).The positive rates of eotaxin-1 and anti CCP antibody in the study group(24.0%,68.0%)were significantly higher than the control group 1(4.0%,20.0%)and 2(0,0),the differences were statistically significant(P<0.05),the positive rate of anti CCP antibody in the control group 1 was significantly higher than the control group 2,the difference was statistically significant(P<0.05),but the difference of positive rates of eotaxin-1 between the control group 1 and the control group 2 was not significant(P>0.05).The serum eotaxin-1 and anti CCP antibody levels were significantly positively correlated with number of tenderness joints(TJC)and range of motion of 28 joints(DAS28)in study group(P<0.05),and serum eotaxin-1 level was significantly positively correlated with number of swollen joints(SJC)(P<0.05),but there was no significant correlation between serum anti CCP antibody level and SJC(P>0.05).Conclusion Serum eotaxin-1 and CCP antibody levels are closely related to disease activity in patients with rheumatoid arthritis.