自噬在药物性肝损伤中的作用研究进展

药物性肝损伤(DILI)是临床上最为常见的一类药源性病变,可导致急性肝衰竭,严重时可造成肝硬化、肝癌甚至死亡.近年来,DILI的发生率呈逐年增加的趋势,成为药物研发失败和已上市药物被撤市的重要原因.自噬是细胞内蛋白质和受损细胞器进行清除的过程,对细胞稳态、质量与数量乃至存活与死亡等调控有着十分重要的意义.越来越多研究表...

Roles of autophagy in drug-induced liver injury:research advances

Drug-induced liver injury(DILI)is the most common drug-induced disease in clinic,which can lead to acute liver failure,cirrhosis,liver cancer and,even death.DILI has been increasing in recent years and is one of the leading causes of failure of drug research and development as well as the withdrawal of marketed drugs.Autophagy is a process of clearance of intracellular proteins and damaged organelles,which is critical to the regulation,cell homeostasis,number and quality,cell survival and death,et al.Increasing studies have shown that autophagy plays important roles in the etiology and development of DILI,involving multiple mechanisms such as oxidative stress,endoplasmic reticulum stress,mitochondrial function,inflammatory response,and apoptosis signaling pathways.This review summerizes the roles of autophagy in DILI and the underlying mechanisms,and discusses the significance and applicability of intervention of autophagy in the prevention and treatment of DILI.