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加味二仙汤联合钙尔奇D对绝经后骨质疏松患者骨密度、骨代谢标志物、视觉模拟评分(VAS)的影响研究
引用本文:陈琳,周雯,王旺.加味二仙汤联合钙尔奇D对绝经后骨质疏松患者骨密度、骨代谢标志物、视觉模拟评分(VAS)的影响研究[J].药物生物技术,2021(1):30-33.
作者姓名:陈琳  周雯  王旺
作者单位:江苏省第二中医院妇科;江苏省第二中医院药剂科
基金项目:江苏省中医药科技发展计划项目(No.YB201932)。
摘    要:探讨加味二仙汤、钙尔奇D联合治疗绝经后骨质疏松症患者对其骨密度、骨代谢标志物、视觉模拟评分法(VAS)得分影响效果.选取该院于2018年7月至2019年5月期间收治的87例绝经后骨质疏松症患者作为本次研究对象并予以随机分组(随机数字表法).对照组(n =43)在常规治疗基础上加用钙尔奇D,研究组(n =44)在对照组基...

关 键 词:绝经后骨质疏松  加味二仙汤  钙尔奇D  骨密度  骨代谢标志物  视觉模拟评分  影响效果

Effect of Jiawei Erxian Decoction Combined with Caltrate D on Bone Mineral Density,Bone Metabolism Markers and Visual Analogue Scale( VAS) in Postmenopausal Osteoporosis Patients
CHEN Lin,ZHOU Wen,WANG Wang.Effect of Jiawei Erxian Decoction Combined with Caltrate D on Bone Mineral Density,Bone Metabolism Markers and Visual Analogue Scale( VAS) in Postmenopausal Osteoporosis Patients[J].Pharmaceutical Biotechnology,2021(1):30-33.
Authors:CHEN Lin  ZHOU Wen  WANG Wang
Institution:(Department of Gynaecology,the No.2 TCM Hospital of Jiangsu Province,Nanjing 210017,China;Departement of Pharmacy,the No.2 TCM Hospital of Jiangsu Prowince,Nanjing 210017,China)
Abstract:To investigate the effect of modified Erxian Decoction and Caltrate D on bone mineral density,bone metabolism markers and visual analogue scale( VAS) scores in postmenopausal osteoporosis patients,87 cases of postmenopausal osteoporosis patients in the author’ s hospital from July 2018 to May 2019 were selected as the research objects and randomly divided into two groups( random number table method). The control group( n= 43) was treated with Caltrate D based on conventional treatment,and in the study group( n = 44) Jiawei Erxian Decoction was added on the basis of the control group. Bone mineral density,bone metabolic markers and VAS scores of the two groups before and after treatment were recorded. Before adopting different treatment regimens,there was no significant difference between the two groups of patients in the detection values of bone mineral density,bone metabolism markers,and VAS scores( P>0. 05). After treatment,the bone mineral density of the lumbar spine L1-4,femoral neck,and greater trochanter of the hip were effectively improved in the two groups of patients compared with before,and the bone mineral density measurements of the study group after treatment were significantly higher than those of the control group( P < 0. 05). The detection values of bone metabolism markers such as OCN,BALP,TRACP-5 b,CTX,and PTH in the two groups of patients were significantly lower than before,and the levels of bone metabolism markers in the study group after treatment were significantly lower than those in the control group( P<0. 05). The decrease in VAS score of the study group was significantly better than that of the control group( P<0. 05).The combined treatment of Jiawei Erxian Decoction and Caerqi D for postmenopausal osteoporosis was more effective and had clinical application value.
Keywords:Postmenopausal osteoporosis  Jiawei Erxian Decoction  Caltrate D  Bone mineral density  Bone metabolism markers  Visual analogue score  Influence effect
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