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Sialoblastoma of the parotid gland
Authors:Mehmet Eken  Gokhan Altin  Sedat Aydin  Umit Hardal  Arif Sanli
Affiliation:1. AP-HP, Hôpital Pitié Salpétrière, Service de chirurgie maxillo-faciale et stomatologie, Paris, F-75013, France;2. Inserm UMR-1132, Paris, France;3. Université Paris Diderot, Sorbonne Paris Cité, Paris, France;4. AP-HP, Hôpital Pitié Salpétrière, Service de radiologie, Paris, F-75013, France;5. UPMC Université Paris 06, F-75005, Paris, France;1. University of Queensland, Princess Alexandra Hospital, Radiation Oncology, Brisbane, QLD 4102, Australia;1. Consultant Oral and Maxillofacial Surgeon, Department of Oral & Maxillofacial Surgery, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark;2. Professor, Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, University of Copenhagen, Copenhagen, Denmark;3. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark;4. Head, Consultant Oral and Maxillofacial Surgeon, Department of Oral & Maxillofacial Surgery, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark;1. Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA;2. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK;1. Research Fellow, First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan;2. Research Fellow, First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan;3. Assistant Professor, Department of Oral Pathology, Osaka University Graduate School of Dentistry, Osaka, Japan;4. Assistant Professor, First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan;5. Associate Professor, First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan;1. Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 384, Houston, TX 77030, USA;2. Cancer Biology Research Center, Sanford Research, 2301 E. 60th St N, Sioux Falls, SD 57104, USA;3. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 66, Houston, TX 77030, USA;4. Chan Soon Shiong Institute of Molecular Medicine, 9920 Jefferson Blvd, Culver City, CA 90230, USA
Abstract:A 3 year-old girl presented with a 6- months history of facial swelling in the region of cheek. Physical examination revealed a firm, non-tender, non- erythematous, mobile, 3 × 3 cm mass in the right cheek. Fine needle aspiration biopsy of the mass demonstrated significiant mitotic activity, slight pleomorfism and atypical cells. A transoral incisional biopsy was also done for accurate diagnosis and the tumor was diagnosed as sialoblastoma. After performing superficial parotidectomy, the tumor was excised with large margins. No adjuvant treatment was given and no recurrence has been noted after 6 months. Despite the rareness of the disease, pathologists and otolaryngologists should always consider the possibility of sialoblastoma of salivary glands in childhood and it can be best described as locally agressive with malignant potential.
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