人工肝支持系统对重型肝炎预后的影响因素分析

目的 :探讨人工肝支持系统对重型肝炎预后的影响因素。方法 :在综合治疗的基础上对 10 9例重型肝炎患者进行人工肝血浆置换 (PE)治疗 ,分析重型肝炎各期、并发症、病毒复制指标 (HBVDNA、HBeAg)等因素对重型肝炎预后的影响。结果 :PE治疗早、中、晚期重型肝炎有效率分别为 82 86%、 60 78%、 2 5 0 0 % ,三者之间差异均有显著性意义 ;对有并发症的重型肝炎其有效率为 5 0 % ,无并发症者为 84 62 % ,两者差异有显著性意义 (P <0 0 1) ;HBVDNA、HBeAg对疗效无显著影响。 结论 :人工肝支持系统是治疗重型肝炎的有效方法 ,应在其早期、无并发症时采用 ,这是取得疗效的关键 ,而病毒复制活跃与否对重型肝炎治疗无显著影响

Analysis of Prognosis Factors of Artificial Liver Support System on Patients with Severe Hepatitis

Objective:To investigate the prognosis factors of artificial liver support system on patients with severe hepatitis.Methods:109 cases of severe hepatitis underwent an ordinary synthetic treatment plus the therapy of plasma exchange(PE).The factors such as the stage of severe hepatitis.severe hepatitis complications and index of virus replication of prognosis of patients with severe hepatitis were analysed.Results:The curative effect was the best on severe hepatitis in early period and the rate of improvement was 82.86%,the middle period was 60.78%,and the late period was 25%.The rate of improvement of severe hepatitis with complications after ALSS therapy was 50%,while the improvement rate of severe hepatitis with no complications was 84.62%(P<0.01).The index of virus replication such as HBV DNA and HBeAg had no effect on severe hepatitis patients with artiticial liver support system.Conclusion:ALSS is a effective therapy for severe hepatitis,and patients with severe hepatitis should be treated in early period without complication.Whethet or not virus replicates have no effect on the rate of improvement of severe hepatitis patients with therary of ALSS.