| 祛浊化痰中药对AS家兔血管成形术后炎性因子表达的影响 |
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| 引用本文： | 王凤荣,王帅,孙淼.祛浊化痰中药对AS家兔血管成形术后炎性因子表达的影响[J].中华中医药学刊,2011(2):241-243. |
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| 作者姓名： | 王凤荣 王帅 孙淼 |
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| 作者单位： | 辽宁中医药大学附属医院心内科;中国医科大学; |
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| 摘 要： | 目的:观察祛浊化痰中药(通脉颗粒)对高脂饮食兔血管成形术后炎性因子hs-CRP、ICAM-1、NF-KB的影响。方法:选择新西兰大耳白兔50只随机分为空白组、模型组、中药组、西药组、中西药组各10只,通过喂养高脂饲料建立家兔AS模型,8周后造血管内皮球囊拉伤模型,测定hs-CRP含量及各组ICAM-1、NF-KBmRNA表达。结果:通脉颗粒可显著下调高脂饮食兔血管成形术后病灶中hs-CRP含量,且能明显降低家兔血清ICAM-1、NF-KBmRNA表达水平(P<0.05)。结论:通脉颗粒能减少AS斑块内的炎性因子表达,并可抑制血管内皮拉伤后相关炎性因子的表达,以减少AS的形成及防止术后再狭窄。其作用机制可能与调脂、抗炎的作用有关。
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| 关 键 词： | 祛浊化痰法 细胞黏附分子(ICAM-1) 高敏C反应蛋白(hs-CRP) 核因子-KB(NF-KB) |
Turbid Phlegm Removing Rabbits by High Fat Diet-related Factors After Angioplasty of Inflammatory |
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| WANG Feng-rong,WANG Shuai,SUN Miao.Turbid Phlegm Removing Rabbits by High Fat Diet-related Factors After Angioplasty of Inflammatory[J].Chinese Archives of Traditional Chinese Medicine,2011(2):241-243. |
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| Authors: | WANG Feng-rong WANG Shuai SUN Miao |
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| Institution: | WANG Feng-rong1,WANG Shuai1,SUN Miao2(1.Department of Cardiology,Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,Liaoning,China,2.China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective: To observe the cured turbid phlegm medicine(Tongmai particles) on the high fat diet rabbits after balloon angioplasty inflammation-associated factor hs-CRP,ICAM-1,NF-kB effects.Methods: 50 New Zealand white rabbits were randomly divided into blank group,model group,group,western medicine group,in the western group 10,through the high fat diet rabbits AS model,to the high fat diet for 8 weeks create vascular endothelial balloon injury model,determination of hs-CRP levels and the group of ICAM-1,NF... |
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| Keywords: | Qu turbid phlegm cell adhesion molecule(ICAM-1) high-sensitivity C-reactive protein(hs-CRP) nuclear factor-KB(NF-KB) |
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