| 冠心合剂对兔颈动脉球囊损伤后MCP-1、C-myc基因表达的影响 |
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| 引用本文： | 祝光礼,周凡,方晓江,魏丽萍.冠心合剂对兔颈动脉球囊损伤后MCP-1、C-myc基因表达的影响[J].中华中医药学刊,2011(1):18-20. |
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| 作者姓名： | 祝光礼 周凡 方晓江 魏丽萍 |
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| 作者单位： | 浙江中医药大学附属广兴医院心内科; |
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| 基金项目： | 杭州市卫生局科研项目(2007B0074) |
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| 摘 要： | 目的:观察冠心合剂对兔颈动脉经皮冠状动脉腔内成形术(PTCA)损伤后对MCP-1、C-myc基因表达的影响。方法:运用球囊原位扩张、拉伤致兔颈总动脉损伤建立PTCA术后内皮损伤模型。从术前3天开始冠心合剂各剂量组予相应剂量冠心合剂每日灌胃给药,分别于第2、4、6周处死动物,取手术侧颈动脉做标本,用RT-PCR法检测兔颈动脉MCP-1、C-myc mRNA的表达。结果:冠心合剂各剂量组MCP-1、C-myc mRNA的表达较模型组降低(P<0.05);冠心合剂各剂量组MCP-1、C-myc mRNA的表达较假手术组升高(P<0.05);大、中、小剂量组组间比较,差异有统计学意义(P<0.05)。结论:冠心合剂可抑制MCP-1、C-myc mRNA的表达,其表达呈剂量依赖性,冠心合剂对PTCA损伤后再狭窄的保护机制可能与抑制MCP-1、C-myc mRNA的表达有关。
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| 关 键 词： | 冠心合剂 球囊损伤 MCP-1 C-myc |
Effect of Guanxin Decoction on MCP-1 and C-myc Expression of Rabbits after Carotid Artery Balloon Injury |
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| ZHU Guang-li,ZHOU Fan,FANG Xiao-jiang,WEI Li-ping.Effect of Guanxin Decoction on MCP-1 and C-myc Expression of Rabbits after Carotid Artery Balloon Injury[J].Chinese Archives of Traditional Chinese Medicine,2011(1):18-20. |
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| Authors: | ZHU Guang-li ZHOU Fan FANG Xiao-jiang WEI Li-ping |
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| Institution: | ZHU Guang-li,ZHOU Fan,FANG Xiao-jiang,WEI Li-ping(Guangxing Hospital Affiliated to Zhengjiang Chinese Medical University,Hangzhou 310007,Zhejiang,China) |
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| Abstract: | Objective:To observe the effect of Guanxin decoction on MCP-1 and C-myc expression after percutaneous transluminal coronary angioplasty(PTCA) of rabbits.Methods:Endothelial injury models were established by using in-situ balloon expansion and strain-induced injury of rabbit carotid artery.The Guanxin decoction groups were fed correspondingly does 3 days before the operation.All the animals were sacrificed at the end of the 2ed,4th and 6th weeks respectively and operated carotid arteries were obtained.The ex... |
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| Keywords: | Guanxin Decoction Balloon Injury MCP-1 C-myc |
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