| 芪参活血颗粒对内毒素血症大鼠动脉收缩性的影响及机制研究 |
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| 引用本文： | 廖玲,齐文杰,王红,张淑文. 芪参活血颗粒对内毒素血症大鼠动脉收缩性的影响及机制研究[J]. 中国中医急症, 2011, 20(1): 75-76,95 |
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| 作者姓名： | 廖玲 齐文杰 王红 张淑文 |
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| 作者单位： | 1. 卫生部北京医院,北京,100730
2. 首都医科大学附属北京友谊医院,北京,100050 |
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| 基金项目： | 北京市中医药管理局资助项目(No.JJ2006-35) |
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| 摘 要： | 目的观察芪参活血颗粒对内毒素血症大鼠动脉收缩活性的影响,并初步探讨其可能的机制。方法将wistar大鼠分为空白对照组、模型组、芪参活血颗粒治疗组、芪参活血颗粒预防组。制备离体胸主动脉环,应用血管张力检测技术检测各组血管环对KCl的反应性并绘制剂量反应曲线。结果与空白对照组相比,内毒素血症大鼠胸主动脉血管环最大收缩反应明显降低（P〈0.05）;与内毒素组相比,芪参活血颗粒预防组和治疗组血管环收缩反应性明显增强;L-NAME处理后,模型组动脉环对KCl的最大收缩能力明显升高,芪参活血颗粒预防组及治疗组升高程度介于两组之间。结论内毒素血症时血管NO过量生成,导致血管的持续舒张状态和对收缩物质的低反应性;芪参活血颗粒能够下调iNOS的表达,减少舒血管物质NO的合成来提高血管对收缩物质的反应性。
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| 关 键 词： | 脂多糖 内毒素血症 芪参活血颗粒 胸主动脉 |
Approach on Effect and Mechanism of Qishenhuoxue Granule on Artery Contractility Changes of Rats with Endotoxaemia |
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| LIAO Ling,QI Wen-jie,WANG Hong,et al Beijing Hospital Beijing Friendship Hospital,Capital Medical University. Approach on Effect and Mechanism of Qishenhuoxue Granule on Artery Contractility Changes of Rats with Endotoxaemia[J]. Journal of Emergency in Traditional Chinese Medicine, 2011, 20(1): 75-76,95 |
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| Authors: | LIAO Ling QI Wen-jie WANG Hong et al Beijing Hospital Beijing Friendship Hospital Capital Medical University |
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| Affiliation: | LIAO Ling1,QI Wen-jie2,WANG Hong2,et al 1 Beijing Hospital(Beijin 1000730) 2 Beijing Friendship Hospital,Capital Medical University(Beijing 100050) |
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| Abstract: | Objective:To observe the effect and the mechanism of Qishenhuoxue Granule on artery contractility changes of rats with endotoxaemia.Methods: Wistar rats were divided into 4 groups randomly including the control group,the LPS group,the treatment with LPS combined with Qishenhuoxue Granule group and the prevention with LPS combined with Qishenhuoxue Granule group.After the thoracic aorta rings were established,their responses to the KCl were detected by the angiotasis testing technology.And then,these results... |
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| Keywords: | Lipopolysaccharide Endotoxemia Qishenhuoxue Granule Thoracic aorta |
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