Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair |
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Authors: | Wei X H Cheng X M Shen J S Wang Z T |
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Affiliation: | Shanghai R&D Center for Standardization of Traditional Chinese Medicine, Shanghai 201203, China. xhweixh@hotmail.com |
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Abstract: | AIM OF THE STUDY: Yueju-Wan (YJ), a traditional Chinese medicinal formula, is commonly used for the treatment of depression-related syndromes in China. This study was conducted to evaluate the antidepressant activity of YJ ethanol extract (YJ-E) and its four different fractions, the petroleum ether fraction (YJ-EA), ethyl acetate fraction (YJ-EB), n-butanol fraction (YJ-EC) and final aqueous fraction (YJ-ED). MATERIALS AND METHODS: Two experimental despair animal models: the mice tail suspension test (TST) and the mice forced swimming test (FST) were used to evaluate the antidepressant activity of YJ-E and its fractions. These extracts or fractions were administered orally for 7 days, while the parallel positive control was given at the same time using fluoxetine hydrochloride (FLU) in TST and imipramine hydrochloride (IMI) in FST respectively. RESULTS: YJ-E high dose (YJ-E2), YJ-EA, YJ-EC and the positive control groups could decrease the duration of immobility in the TST and FST and have no significant changes in locomotor activity. YJ-E low dose (YJ-E1), YJ-EB, YJ-ED and the vehicle solvent (VEH) control group have no obvious effect on these same tests. CONCLUSIONS: In these despair animal models, YJ ethanol extract, the petroleum ether fraction and n-butanol fraction show potent antidepressant effects. The petroleum ether fraction and n-butanol fraction appear to be the active fractions of YJ-E. |
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Keywords: | YJ, Yueju-Wan YJ-E, Yueju-Wan ethanol extract YJ-E1, Yueju-Wan ethanol extract low dose YJ-E2, Yueju-Wan ethanol extract high dose YJ-EA, the petroleum ether fraction of Yueju-Wan ethanol extract YJ-EB, the ethyl acetate fraction of Yueju-Wan ethanol extract YJ-EC, the n-butanol fraction of Yueju-Wan ethanol extract YJ-ED, the aqueous fraction of Yueju-Wan ethanol extract TST, tail suspension test FST, forced swimming test FLU, fluoxetine hydrochloride IMI, imipramine hydrochloride VEH, vehicle solvent NIMH, National Institute of Mental Health TCM, traditional Chinese medicine |
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