| 质子泵抑制药药动学的研究进展 |
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| 引用本文： | 苏长海,王星.质子泵抑制药药动学的研究进展[J].中国新药与临床杂志,2010(3). |
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| 作者姓名： | 苏长海 王星 |
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| 作者单位： | 鄂尔多斯市中心医院药剂科; |
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| 摘 要： | 质子泵抑制药(PPIs)是临床中主要的抑酸药,奥美拉唑、埃索美拉唑、兰索拉唑、泮托拉唑、雷贝拉唑等PPIs在药动学方面存在很大的差异(如生物利用度、代谢型、药物的相互作用、生物特异性等方面)。近年来,有很多文献报道了P450酶(CYP)代谢对PPIs的药动学影响。临床证据证明PPIs安全有效,但仍有很多患者对PPIs耐药,所以在实践中应该选择性应用PPIs。
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| 关 键 词： | 质子泵 细胞色素P450 药动学 CYP2C19 CYP3A4 质子泵抑制药 |
Progress in pharmacokinetics of proton pump inhibitors |
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| SU Chang-hai,WANG Xing.Progress in pharmacokinetics of proton pump inhibitors[J].Chinese Journal of New Drugs and Clinical Remedies,2010(3). |
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| Authors: | SU Chang-hai WANG Xing |
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| Institution: | SU Chang-hai,WANG Xing (Department of Pharmacy,Erdos Center Hospital,Erdos NEI MONGOL 017000,China) |
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| Abstract: | Proton pump inhibitors ( PPIs) are commonly prescribed to treat acid-related diseases.Omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole are very different in their pharmacokinetics properties ( e.g., bioavailability, metabolic pattern, interaction potential, genetic variability). Many researches reported so far that cytochrome P450 (CYP) could affect the pharmacokinetics of PPIs. Although there is considerable evidence to prove their clinical efficacy and safety, there are still a certai... |
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| Keywords: | proton pump cytochrome P450 pharmacokinetics CYP2C19 CYP3A4 proton pump inhibitors |
| 本文献已被 CNKI 等数据库收录！ |
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