| 他克莫司对肾移植患者全血白细胞化学发光的影响 |
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| 引用本文： | 刘世霆,杨凌.他克莫司对肾移植患者全血白细胞化学发光的影响[J].医药导报,2002,21(11):705-706. |
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| 作者姓名： | 刘世霆 杨凌 |
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| 作者单位： | 第一军医大学南方医院药学部,广州,510515 |
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| 摘 要： | 目的:探讨他克莫司对肾移植患者全血白细胞化学发光的影响.方法:对46例肾移植患者用化学发光仪测定酵母多糖刺激引起的全血白细胞呼吸爆发,微粒酶联免疫法测定全血他克莫司浓度.结果:与正常对照组相比,他克莫司用药组患者的全血白细胞化学发光强度显著下降(P＜0.05);移植患者血清直接抑制大鼠腹腔巨噬细胞的化学发光强度,他克莫司浓度与全血白细胞化学发光呈负相关(P＜0.05).结论:他克莫司抑制白细胞的呼吸爆发.
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| 关 键 词： | 他克莫司 肾移植 化学发光 |
| 文章编号： | 1004-0781(2002)11-0705-02 |
| 修稿时间： | 2001年10月26 |
Effect of Tacrolimus on Whole Blood Neutrophils Chemiluminesc ence of Renal Transplant Patients |
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| LIU Shi ting,YANG Ling.Effect of Tacrolimus on Whole Blood Neutrophils Chemiluminesc ence of Renal Transplant Patients[J].Herald of Medicine,2002,21(11):705-706. |
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| Authors: | LIU Shi ting YANG Ling |
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| Abstract: | Objective:To examine the possible inhibitory effect of tacrolimus on luminol dependent chemiluminescence (CL) of whole blood neutrophils in renal transplant patients. Methods:Luminol dependent CL was used to measure active oxygen species generation in respirtory burst of whole blood neutrophils stimulated by zymosan A. Microparticle enzyme immunoassay was used to monitor the blood concentration of tacrolimus. Results:CL values of tacrolimus group ( n =46) decreased in comparison with those of normal group ( n =10) ( P <0.05). The serum of renal transplant patients directly inhibited respiratory burst of rats in a concentration dependent manner ( P <0.05). Conclusion:Tacrolimus inhibits the phagocytic activity of neutrophils in renal transplant patients. |
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| Keywords: | Tacrolimus Kindney transplantation Chemiluminescence |
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