| 脂联素基因变异与2型糖尿病的相关性 |
| |
| 引用本文： | 汝颖,王长江,王佑民,章秋,胡红琳,陈明卫. 脂联素基因变异与2型糖尿病的相关性[J]. 中华内分泌代谢杂志, 2005, 21(4): 322-323 |
| |
| 作者姓名： | 汝颖 王长江 王佑民 章秋 胡红琳 陈明卫 |
| |
| 作者单位： | 合肥,安徽医科大学第一附属医院内分泌科 |
| |
| 基金项目： | 安徽省教委科研基金资助项目(2003kj229)，安徽省卫生厅科研基金资助项目(2002A008) |
| |
| 摘 要： | 聚合酶链反应单链构象多态性和基因测序法观察脂联素基因I164T突变与中国安徽地区汉族人2型糖尿病的关系。受试者中未发现I164T突变,但在糖耐量异常组中,发现该基因的H142P新突变。提示I164T突变可能不是本组2型糖尿病的重要遗传因素,且该基因位点突变具有种族异质性。
|
| 关 键 词： | 脂联素 糖尿病 2型 突变 |
| 收稿时间： | 2004-01-21 |
| 修稿时间： | 2004-01-21 |
Association of adiponectin gene variants with type 2 diabetes |
| |
| RU Ying,WANG Chang-jiang,WANG You-min,Zhang Qiu,HU Hong-lin,CHEN Ming-wei. Association of adiponectin gene variants with type 2 diabetes[J]. Chinese Journal of Endocrinology and Metabolism, 2005, 21(4): 322-323 |
| |
| Authors: | RU Ying WANG Chang-jiang WANG You-min Zhang Qiu HU Hong-lin CHEN Ming-wei |
| |
| Abstract: | Polymerase chain reaction-single strand conformation polymorphism and DNA sequencing were used to investigate the association of I164T mutation in adiponectin gene with type 2 diabetes in Chinese Hansin Anhui province.I164T variation was not found in the studied population and a new mutation-H142P was found in subjects with abnormal glucose tolerance. The result reveals that I164T mutation is not a major predisposing genetic factor for type 2 diabetes and the mutation in adiponectin gene is different in races genetically. |
| |
| Keywords: | Adiponectin Diabetes mellitus type 2 Mutation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
