|
|||||
|
|
| 斑蝥酸钠抑制人胃癌裸鼠皮下移植瘤生长及作用机制的实验研究 | |
| 引用本文： | 梁枫,王明艳,黄文斌,李爱剑.斑蝥酸钠抑制人胃癌裸鼠皮下移植瘤生长及作用机制的实验研究[J].中国基层医药,2008,15(4). |
| 作者姓名： | 梁枫 王明艳 黄文斌 李爱剑 |
| 作者单位： | 1. 安徽中医药高等专科学校医疗系,安徽省芜湖,241000 2. 南京中医药大学基础医学院 3. 南京医科大学附属南京市第一医院病理科 |
| 基金项目： | 安徽省教育厅自然科学研究项目 |
| 摘 要： | 目的 初步探讨斑蝥酸钠对人胃癌裸鼠皮下移植瘤生长的作用及其可能的作用机制.方法 建立人胃癌细胞系BGC823裸鼠皮下移植瘤模型,观察斑蝥酸钠对移植瘤生长的影响,同时应用免疫组织化学和TUNEL法分别检测斑蝥酸钠作用前后移植瘤细胞的增殖活性和细胞凋亡情况.结果 不同浓度的斑蝥酸钠均能明显抑制裸鼠皮下移植瘤的生长(P＜0.01);斑蝥酸钠作用后肿瘤细胞的增殖活性明显低于作用前(P＜0.01);斑蝥酸钠作用后肿瘤细胞的凋亡指数显著高于对照组(P＜0.01).结论 斑蝥酸钠对人胃癌棵鼠皮下移植瘤的生长具有明显的抑制作用,其作用机制可能是通过抑制肿瘤细胞增殖或诱导肿瘤细胞凋亡而实现的. |
| 关 键 词： | 胃肿瘤 斑蝥素 肿瘤移植 小鼠 裸 |
Effect of sodium cantharidinate on the growth of human gastric cancer grafted onto nude mice |
|
| LIANG Feng,WANG Ming-Yan,HUANG Wen-bin,LI Ai-jian.Effect of sodium cantharidinate on the growth of human gastric cancer grafted onto nude mice[J].Chinese Journal of Primary Medicine and Pharmacy,2008,15(4). | |
| Authors: | LIANG Feng WANG Ming-Yan HUANG Wen-bin LI Ai-jian |
| Abstract: | Objective To study the effect of sodium cantharidinate on the growth of human gastric cancer grafted onto nude mice. Methods Nude mice xenograft models of human gastric cancer were established.BGC823was injected peritoneal and the mice were weighed. The proliferating and apoptosis rates of xenografta was evaluated by TUNEL assay and immunohistochemical staining respectively. Results The xenografts were obviously inhibited with various dosage of sodium cantharidinate(P＜0.01 ), the proliferating rate of turnout cells after using sodium cantharidinate was lower than that before using sodium cantharidinate(P＜0.01 ), but apoptosis rate of tumour ceils after using sodium cantharidinate was higher than that before using sodium cantharidinate(P＜0.01 ). Conclusion Sodium cantharidinate can inhibit gastric cancer growth by inhibiting tumour cell proliferating or inducing cell apoptosls. |
| Keywords: | Stomach neoplasms Cantharidin Neoplasm transplantation Mice nude |
| 本文献已被 万方数据 等数据库收录！ | |