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Rafts, anchors and viruses--a role for glycosylphosphatidylinositol anchored proteins in the modification of enveloped viruses and viral vectors |
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| Authors: | Metzner Christoph Salmons Brian Günzburg Walter H Dangerfield John A |
| Affiliation: | a Institute of Virology, Department of Pathobiology, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria b Christian Doppler Laboratory for Gene Therapeutic Vector Development, Veterinärplatz 1, 1210 Vienna, Austria c Austrianova Singapore Pte. Ltd., #05-518 Centros, 20 Biopolis Way, Singapore 138668, Singapore d Christian Doppler Laboratory Foreign Module for Virology-Nanotechnology, #05-518 Centros, 20 Biopolis Way, Singapore 138668, Singapore |
| Abstract: | Lipid rafts have been proposed as sites for the assembly of a number of viruses and are considered to play a major role in pseudotyping events. As a consequence, host glycosylphosphatidylinositol (GPI) anchored proteins commonly associated with lipid rafts can be found being incorporated into viral lipid envelopes with beneficial consequences for viral replication. In this review we will look at the link between lipid rafts, GPI-anchored proteins and retroviral particles and how these relationships can be exploited for the modification of enveloped viruses. |
| Keywords: | Viral vectors Gene therapy Vaccine development GPI-anchored proteins Painting |
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