Serotype-specific and cross-reactive neutralizing antibody responses in cynomolgus monkeys after infection with multiple dengue virus serotypes |
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| Authors: | Ito Mikako Katakai Yuko Ono Fumiko Akari Hirofumi Mukai Ryo-Zabro Takasaki Tomohiko Kotaki Akira Kurane Ichiro |
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| Affiliation: | (1) Department of Virology 1, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjyuku-ku, Tokyo 162-8640, Japan;(2) The Corporation for Production and Research of Laboratory Primates, 1 Yahatadai, Tsukuba 305-0843, Japan;(3) Laboratory of Disease Control, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, 1 Hachimandai, Tsukuba Ibaraki, 305-0843, Japan;(4) Present address: Section of Comparative Immunology and Microbiology, Center forHuman Evolution Modeling Research, Primate Research Institute, Kyoto University, Inuyama Aichi, 484-8506, Japan |
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| Abstract: | Neutralizing antibody responses were examined in monkeys after dengue virus infections. In monkeys that had been infected once or twice with DENV-2, neutralizing antibody was cross-reactive with all four serotypes after secondary or tertiary infection with DENV-3. In monkeys that had been inoculated with DENV-1 and DENV-2 in the primary and secondary infections, neutralizing antibody titers did not increase after tertiary infection with DENV-3. These results indicate that antibody responses after secondary and tertiary infections with different serotypes are cross-reactive with all four serotypes, consistent with what has been observed in humans, and suggest that monkeys are useful for determining neutralizing antibody responses. |
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