| 尿液中基质金属蛋白酶-2和基质金属蛋白酶-9检测对膀胱癌的诊断价值 |
| |
| 引用本文： | 王春红,金戈,颜南,黄洪武,吴菲. 尿液中基质金属蛋白酶-2和基质金属蛋白酶-9检测对膀胱癌的诊断价值[J]. 实用口腔医学杂志, 2011, 0(10): 963-965 |
| |
| 作者姓名： | 王春红 金戈 颜南 黄洪武 吴菲 |
| |
| 作者单位： | 沈阳医学院;江苏省昆山市公安局;沈阳市沈洲医院; |
| |
| 基金项目： | 沈阳医学院2011年学院青年基金(20112059) |
| |
| 摘 要： | 目的探讨尿液中基质金属蛋白酶(MMP)-2和MMP-9水平与膀胱癌发生和发展的关系及早期诊断的价值。方法测定101例膀胱癌患者,88例良性泌尿系统疾病患者及51名健康人尿液中MMP-2和MMP-9的水平。比较3组尿液中MMP-2和MMP-9水平的差异,并比较膀胱癌患者尿液MMP-2和MMP-9水平与肿瘤病理分级的关系。应用受试者工作特征曲线(ROC)进行评价,判断两者的最优截断点并计算其准确度、阳性预测值和阴性预测值。结果膀胱癌患者组尿液中MMP-2和MMP-9水平显著高于良性泌尿系统疾病患者组和健康对照组(P<0.01),Ⅱ级和Ⅲ级膀胱癌患者尿液中MMP-2和MMP-9水平明显高于Ⅰ级(P<0.01)。尿液MMP-2的ROC曲线下面积为0.854,最优截断点为2.4ng/mg蛋白时,准确度为80.8%,灵敏度为81.2%,特异度81.3%;MMP-9的ROC曲线下面积为0.906,最优截断点为6.2ng/mg蛋白时,准确度为87.5%,灵敏度为85.1%,特异度为89.2%;MMP-2和MMP-9联合诊断的灵敏度达到98.0%,特异度为96.4%,准确度为90.0%。结论尿液MMP-2和MMP-9的检测可以用于对膀胱癌的初步诊断,可将其作为膀胱癌的筛选检查项目。
|
| 关 键 词： | 膀胱肿瘤 基质金属蛋白酶 尿 |
Diagnostic value of MMP-2 and MMP-9 in urine for bladder cancer |
| |
| WANG Chun-hong,JIN Ge,YAN Nan,HUANG Hong-wu,WU Fei.Shenyang Medical College,Liaoning ,China. Diagnostic value of MMP-2 and MMP-9 in urine for bladder cancer[J]. Journal of Practical Stomatology, 2011, 0(10): 963-965 |
| |
| Authors: | WANG Chun-hong JIN Ge YAN Nan HUANG Hong-wu WU Fei.Shenyang Medical College Liaoning China |
| |
| Affiliation: | WANG Chun-hong,JIN Ge,YAN Nan,HUANG Hong-wu,WU Fei.Shenyang Medical College,Liaoning 110034,China |
| |
| Abstract: | Objective To assess the diagnostic value of MMP-2 and MMP-9 in urine for bladder cancer,and to study the relationship between MMP-2 and MMP-9 levels and the development of bladder cancer.Methods Urinary MMP-2 and MMP-9 levels were detected using enzyme linked immunosorbent assay(ELISA) in 101 patients with bladder cancer,eighty-eight patients with benign urological lesions and fifty-one healthy volunteers.MMP-2 and MMP-9 levels were compared in three groups,and the relationship in different tumor stage grou... |
| |
| Keywords: | Bladder neoplasms Matrix metalloproteinase Urine |
| 本文献已被 CNKI 等数据库收录！ |
|
