A potential inhibitor of rat aortic vascular smooth muscle cell proliferation from the pollen of Typha angustata |
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Authors: | Nguyen Xuan Nhiem Phan Van Kiem Chau Van Minh Jung-Jin Lee Ja Hyeong Ku Chang-Seon Myung Young Ho Kim |
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Affiliation: | (1) Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan;(2) Iskra Industry Co., Ltd., 1-14-2 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan;(3) College of Pharmacy, Jiangxi University of Traditional Medicine, 330006 Nanchang, Jiangxi, China;(4) Heilongjiang University of Traditional Chinese Medicine, 24 Hepin Road, 150040 Harbin, China; |
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Abstract: | By various chromatographic methods, three flavonoids, (2S)-naringenin (1), isorhamnetin 3-O-(2-O-α-l-rhamnopyranosyl) β-d-glucopyranoside (2), typhaneoside (3), and two sterol glycosides, β-sitosterol-3-O-(6-octadecanoyl) β-d-glucopyranoside (4) and β-sitosterol-3-O-(6-octadeca-9Z,12Z-dienoyl) β-d-glucopyranoside (5), were isolated from the pollen of Typha angustata. Their structures were determined on the basis of spectroscopic analyses. The flavonoids (1–3) were evaluated for their effects on the viability and proliferation of rat aortic smooth muscle cells. (2S)-naringenin (1) significantly inhibited cell proliferation in a dose-dependent manner without cytotoxic at concentrations of 30, and 50 μM; it reduced the number of cells following PDGF-BB treatment to 1.83 ± 0.30 × 104 and 2.20 ± 0.60 × 104 cells/well, respectively. These findings suggest that (2S)-naringenin has antiproliferative effects on aortic smooth muscle cells. |
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